The signaling pathway of neurotrophic factor biosynthesis
The signaling pathway of neurotrophic factor biosynthesis
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DOI：
10.1358/dnp.2002.15.5.840042
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发表时间：
2002-06-01
影响因子：
--
通讯作者：
Nakahata, N
中科院分区：
文献类型：
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作者：
Obara, Y;Nakahata, N
存在各种神经营养因子，如神经生长因子（NGF）、脑源性神经营养因子（BDNF）、胶质细胞系源性神经营养因子（GDNF）和白细胞介素-6（IL-6），它们对于促进中枢神经系统中的神经元存活（防止细胞凋亡）、分化和再生是必需的。神经营养因子、神经营养因子样物质和神经营养因子生物合成的诱导剂对严重的神经元疾病如阿尔茨海默病或脑中的创伤性、化学性和缺血性病变具有巨大的治疗潜力。阐明神经营养因子生物合成的机制对于理解刺激神经营养因子产生的药物的开发是重要的。本文综述了NGF、BDNF、GDNF和IL-6的生物合成机制，并对可能促进神经营养因子生物合成的药物进行了讨论。(C)2002年，《科学》杂志。All rights reserved.
There are various neurotrophic factors, such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) and interleukin-6(IL-6), which are essential for the promotion of neuronal survival (prevention of apoptosis), differentiation and regeneration in the central nervous system. Neurotrophic factors, neurotrophic factor-like substances and inducers of neurotrophic factor biosynthesis have enormous therapeutic potential for serious neuronal diseases such as Alzheimer's disease or traumatic, chemical and ischemic lesions in the brain. The clarification of the mechanism in neurotrophic factor biosynthesis is important in understanding the development of the drugs that stimulate neurotrophic factor production. In this review, we describe these mechanisms in the biosynthesis of NGF, BDNF, GDNF and IL-6, and also discuss the drugs that could possibly promote neurotrophic factor biosynthesis. (C) 2002 Prous Science. All rights reserved.