Emerging roles of transforming growth factor signaling in wet age-related macular degeneration
Emerging roles of transforming growth factor signaling in wet age-related macular degeneration
复制标题
转化生长因子信号在湿性年龄相关性黄斑变性中的新作用
DOI：
10.1093/abbs/gmy145
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Ying Ying
中科院分区：
文献类型：
--
作者：
Wang Kai;Li Haoran;Sun Ruipu;Liu Chaxian;Luo Yunfei;Fu Shuhua;Ying Ying
Age-related macular degeneration (AMD) is one of the major causes of irreversible blindness among aging populations in developed countries and can be classified as dry or wet according to its progression. Wet AMD, which is characterized by angiogenesis on the choroidal membrane, is uncommonly seen but more severe. Controlling or completely inhibiting the factors that contribute to the progression of events that lead to angiogenesis may be an effective strategy for treating wet AMD. Emerging evidence has shown that transforming growth factor-β (TGF-β) signaling plays a significant role in the progression of wet AMD. In this review, we described the roles of and changes in TGF-β signaling in the development of AMD and discussed the mechanisms of the TGF-β superfamily in choroidal neovascularization (CNV) and wet AMD, including the modulation of angiogenesis-related factors, inflammation, vascular fibrosis, and immune responses, as well as cross-talk with other signaling pathways. These remarkable findings indicate that TGF-β signaling is a potential target for wet AMD treatment.
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TGF-β通过激光诱导的与湿年龄相关的黄斑变性的小鼠中的SMAD2/3-VEGF/TNF-α信号参与脉络膜新血管化。
影响因子：
4.6
作者：
Wang X;Ma W;Han S;Meng Z;Zhao L;Yin Y;Wang Y;Li J
通讯作者：
Li J
影响因子：
--
作者：
Ntumba K;Akla N;Oh SP;Eichmann A;Larrivée B
通讯作者：
Larrivée B
阻断卵泡抑素样 1 可减轻博莱霉素诱导的小鼠肺纤维化
DOI：
10.1084/jem.20121878
发表时间：
2015-02-09
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Dong Y;Geng Y;Li L;Li X;Yan X;Fang Y;Li X;Dong S;Liu X;Li X;Yang X;Zheng X;Xie T;Liang J;Dai H;Liu X;Yin Z;Noble PW;Jiang D;Ning W
通讯作者：
Ning W
影响因子：
5
作者：
Fisichella, Vincenzo;Giurdanella, Giovanni;Bucolo, Claudio
通讯作者：
Bucolo, Claudio
DOI：
10.1097/iae.0b013e3181ad255f
发表时间：
2009-06
期刊：
Retina
影响因子：
--
作者：
A. Brucker
通讯作者：
A. Brucker