The effects of amino acid/protein supplementation in patients undergoing hemodialysis: A systematic review and meta-analysis of randomized controlled trials
The effects of amino acid/protein supplementation in patients undergoing hemodialysis: A systematic review and meta-analysis of randomized controlled trials
复制标题
氨基酸/蛋白质补充对血液透析患者的影响：随机对照试验的系统评价和荟萃分析
DOI：
10.1016/j.clnesp.2021.04.027
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发表时间：
2021
影响因子：
3
通讯作者：
Tamaki Akira
中科院分区：
文献类型：
--
作者：
Matsuzawa Ryota;Yamamoto Shohei;Suzuki Yuta;Abe Yoshifumi;Harada Manae;Shimoda Takahiro;Imamura Keigo;Yamabe Sachi;Ito Haruka;Yoshikoshi Shun;Imai Hiroto;Onoe Hinano;Matsunaga Atsuhiko;Tamaki Akira
背景与目标我们评估了氨基酸/蛋白质补充干预措施对血液透析患者肌肉质量、肌肉力量和身体功能的功效。方法这项系统回顾和荟萃分析通过系统搜索 4 个电子数据库和从数据库建立到 2020 年 8 月合格研究的参考文献，确定了潜在的研究。我们仅纳入了报告氨基酸/蛋白质补充对血液透析患者肌肉质量、肌肉力量和身体功能功效的随机对照试验。结果 6529 条独特引用根据记录，4 项研究（包括 243 名参与者）被选择纳入荟萃分析。尽管干预组和对照组之间的肌肉质量和肌肉力量没有显着差异，但补充氨基酸/蛋白质可显着改善身体功能（穿梭行走，MD 32.7，95% CI 21.7 至 43.7，P < 0.001；步态速度，MD 0.07，95% CI 0.01 至 0.13，P = 0.02；计时起身走，MD -0.42，95% CI -0.68 至 -0.15，P = 0.002）在血液透析患者中。结论我们证实了氨基酸/蛋白质补充对接受血液透析的患者的身体功能有积极作用。然而，证据仍然不足，需要更严格设计的高质量随机对照试验。
Background & aimsWe evaluated the efficacy of the intervention consisting of amino acid/protein supplementation on muscle mass, muscle strength and physical function in patients on hemodialysis.MethodsThis systematic review and meta-analysis identified potential studies through a systematic search of 4 electronic databases and references from eligible studies from database inception to August 2020. We included only randomized controlled trials reporting the efficacy of amino acid/protein supplementation on muscle mass, muscle strength and physical function in patients on hemodialysis.ResultsOf 6529 unique citation records, 4 studies including 243 participants were selected for inclusion in the meta-analysis. Although there were no significant differences in muscle mass and muscle strength between the intervention and control groups, amino acid/protein supplementation was shown to significantly improve physical function (shuttle walk, MD 32.7, 95% CI 21.7 to 43.7, P < 0.001; gait speed, MD 0.07, 95% CI 0.01 to 0.13, P = 0.02; timed up and go, MD -0.42, 95% CI -0.68 to −0.15, P = 0.002) in patients on hemodialysis.ConclusionsWe confirmed the positive effect of amino acid/protein supplementation on physical function in people undergoing hemodialysis. However, there is still insufficient evidence, and more rigorously designed randomized controlled trials with high quality are needed.