Epinephrine, norepinephrine, glucagon, and growth hormone release in association with physiological decrements in the plasma glucose concentration in normal and diabetic man.
Epinephrine, norepinephrine, glucagon, and growth hormone release in association with physiological decrements in the plasma glucose concentration in normal and diabetic man.
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DOI：
10.1210/jcem-51-4-877
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发表时间：
1980-10
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影响因子：
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通讯作者：
Julio V. Santiago;William L. Clarke;Suresh D. Shah;Philip E. Cryer
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文献类型：
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作者：
Julio V. Santiago;William L. Clarke;Suresh D. Shah;Philip E. Cryer
潜在重要的葡萄糖反调节因子的释放（肾上腺素，去甲肾上腺素，胰高血糖素，GH，和皮质醇）在Biostator控制的血糖浓度从95 mg/dl的高生理水平降低到60 mg/dl的低生理水平期间进行了研究（5名正常受试者和5名胰岛素依赖型糖尿病患者）和6名受试者（3名正常受试者和3名胰岛素依赖型糖尿病患者）中200 - 100 mg/dl的超生理水平。血浆葡萄糖浓度从95 mg/dl降低至60 mg/dl与早期糖尿病相关。（+30至+40 min）增量[此处最大值表示为平均基线的百分比（平均值± SE）]血浆肾上腺素（529 ± 144; P < 0.02），去甲肾上腺素（146 ± 12; P < 0.01），胰高血糖素（123 ± 13; P < 0.05）和晚期（+75 min）血浆GH水平升高血浆皮质醇（132 ± 15）在治疗后105分钟内明显升高，但无统计学意义（P> 0.05）。
The release of potentially important glucose counter-regulatory factors (epinephrine, norepinephrine, glucagon, GH, and cortisol) was studied during Biostator-controlled reductions in the plasma glucose concentration from the high physiological level of 95 mg/dl to the low physiological level of 60 mg/dl in 10 subjects (5 normal subjects and 5 patients with insulin-dependent diabetes) and from the supraphysiological level of 200 to 100 mg/dl in 6 subjects (3 normal subjects and 3 patients with insulin-dependent diabetes). Reductions in the plasma glucose concentration from 95 to 60 mg/dl were associated with early (+30 to +40 min) increments [here with the maximal values expressed as the percent of the mean baseline (mean ± SE)] in plasma epinephrine (529 ± 144; P < 0.02), norepinephrine (146 ± 12; P < 0.01), and glucagon (123 ± 13; P < 0.05) and a late (+75 min) increment in plasma GH (2504 ± 1065; P < 0.05); an apparent late (+105 min) increment in plasma cortisol (132 ± 15) was not statistically signif...