Distinct Pathological Features of the Gallyas‐ and Tau‐positive Glia in the Parkinsonism‐Dementia Complex and Amyotrophic Lateral Sclerosis of Guam
Distinct Pathological Features of the Gallyas‐ and Tau‐positive Glia in the Parkinsonism‐Dementia Complex and Amyotrophic Lateral Sclerosis of Guam
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关岛帕金森病-痴呆症和肌萎缩侧索硬化症中 Gallyas 和 Tau 阳性胶质细胞的独特病理特征
DOI：
10.1097/00005072-199703000-00010
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发表时间：
1997
影响因子：
3.2
通讯作者：
Thomas N. Chase
中科院分区：
文献类型：
--
作者：
Kiyomitsu Oyanagi;T. Makifuchi;T. Ohtoh;Kwang;D. Gajdusek;Thomas N. Chase
我们检查了50例帕金森病痴呆综合征的关岛（关岛PDC）。10名患有肌萎缩侧索硬化症（ALS）的关岛患者，5名患有PDC和ALS（PDC-ALS）的患者，以及20名非PDC非ALS关岛人，他们在1979年至1982年期间进行了尸检，特别注意神经胶质内含物。在关岛PDC和PDC-ALS患者的大脑中，除了广泛的神经元缠结（NFT）外，在许多胶质细胞中观察到Gallyas阳性和tau免疫阳性的胞浆内包涵体。星形胶质细胞中可见颗粒状模糊包涵体，少突胶质细胞中可见一些新月形/卷曲包涵体。杏仁核、下橄榄核和脊髓外侧索内可见许多颗粒状模糊包涵体。新月形/卷曲包涵体主要见于丘脑前核、运动皮质、中脑被盖、延髓锥体和脊髓外侧索。颗粒状模糊夹杂物以前从未报道过，在关岛PDC和PDC-ALS的新月形/卷曲夹杂物的地形分布不同于以前报道的其他NFT形成疾病。这些研究结果表明，关岛PDC和PDC-ALS不仅涉及神经元，而且神经胶质细胞，其形态和地形的差异，从其他神经纤维瘤形成疾病可能提供进一步的见解，其独特的发病机制，从而证明是有用的诊断。
We examined 50 patients with parkinsonism-dementia complex of Guam (Guam PDC). 10 Guamanian patients with amyotrophic lateral sclerosis (ALS), 5 patients with combined PDC and ALS (PDC-ALS), and 20 non-PDC non-ALS Guamanians, who had been autopsied between 1979 and 1982, paying special attention to glial inclusions. Gallyas-positive and tau-immunopositive intracytoplasmic inclusions were observed in many of the glial cells, in addition to extensive neurofibrillary tangles (NFTs) in the brains of Guam PDC and PDC-ALS patients. Granular hazy inclusions were seen in the astrocytes, and some crescent/coiled inclusions were observed in the oligodendroglia. Many granular hazy inclusions were observed in the amygdaloid nucleus, inferior olivary nucleus, and lateral funiculus of the spinal cord. The crescent/coiled inclusions were observed predominantly in the anterior nucleus of the thalamus, motor cortex, midbrain tegmentum, pyramids of the medulla oblongata, and lateral funiculus of the spinal cord. The granular hazy inclusions have never been reported previously, and the topographic distribution of the crescent/coiled inclusions in Guam PDC and PDC-ALS differs from those reported previously in other NFT-forming diseases. These findings indicate that Guam PDC and PDC-ALS involve not only neurons but also glia, and that their morphological and topographic differences from other NFT-forming diseases may provide further insights into their distinct etiopathogenesis, and thus prove useful for diagnosis.