Group B streptococci elicit leukotriene B4 and interleukin-8 from human monocytes: neonates exhibit a diminished response.
Group B streptococci elicit leukotriene B4 and interleukin-8 from human monocytes: neonates exhibit a diminished response.
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B 族链球菌从人类单核细胞中引发白三烯 B4 和白细胞介素 8：新生儿的反应减弱。
DOI：
10.1093/infdis/172.2.420
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Edwards,MS
中科院分区：
文献类型：
--
作者：
Rowen,JL;Smith,CW;Edwards,MS
与成人细胞相比，新生儿单核细胞功能减弱。通过化学引诱剂招募中性粒细胞的能力尚未在人类中得到评估。B群链球菌（GBS）诱导的趋化剂释放模式也未知。用GBS刺激成人和脐带血单核细胞。用上清液作为诱食剂，置于盲孔室中；新生儿上清的迁移减少。白介素-8 （IL-8）和白三烯B4（LTB4）在GBS或脂多糖的作用下被成年单核细胞大量释放。释放IL-8不需要对GBS进行调理。成人单核细胞在未激活的GBS刺激下比激活的GBS刺激下释放更多的ltb4；新生儿的LTB4产量没有增加。IL-8和ltb4在GBS反应中释放的化学引诱剂活性占大部分。ltb4和IL-8的产生减少可能导致新生儿对GBS的不良反应。
Neonatal monocytes have diminished function compared with adult cells. The ability to recruit neutrophils through elaboration of chemoattractants has not been evaluated in humans. The pattern of chemoattractant release induced by group B streptococci (GBS) also is unknown. Adult and cord blood monocytes were stimulated with GBS. Supernatants were used as the attractant in blind well chambers; migration to neonatal supernatants was diminished. Interleukin-8 (IL-8) and leukotriene B4(LTB4) were released in greater quantities by adult monocytes in response to either GBS or lipopolysaccharide. Opsonization of GBS was not required for IL-8 release. Adult monocytes released more LTB4when stimulated with unopsonized GBS than with opsonized GBS; the neonate's LTB4 production did not increase. IL-8 and LTB4accounted for the majority of chemoattractant activity released in response to GBS. Decreased production of LTB4and IL-8 may contribute to the neonate's poor host response to GBS.