2ND-TRIMESTER SERUM COTININE LEVELS IN NONSMOKERS IN RELATION TO BIRTH-WEIGHT
2ND-TRIMESTER SERUM COTININE LEVELS IN NONSMOKERS IN RELATION TO BIRTH-WEIGHT
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DOI：
10.1016/s0002-9378(88)80114-5
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发表时间：
1988-08-01
影响因子：
9.8
通讯作者：
MCCARTHY, JE
中科院分区：
文献类型：
--
作者：
HADDOW, JE;KNIGHT, GJ;MCCARTHY, JE
在这项研究中，首次通过血清可替宁测量来评估出生体重和被动暴露于烟草烟雾之间的关系。在怀孕中期采集血液样本的1231名非吸烟白人妇女中，31.4%的人血清可替宁水平在1.0至9.9 ng/ml之间，因此被认为被动暴露于烟草烟雾中。被动吸烟妇女的婴儿平均出生体重比非被动吸烟妇女的婴儿低107克，在应用了包括已知的主要出生体重相关协变量的多变量分析后，这种差异仍然存在。这些发现与被动暴露于烟草烟雾和出生体重之间的因果关系是一致的，并表明剂量-反应关系可能不是线性的。
In this study the relationship between birth weight and passive exposure to tobacco smoke is assessed for the first time by serum cotinine measurements. Among 1231 nonsmoking white women whose blood was sampled during the second trimester of pregnancy, 31.4% had serum cotinine levels between 1.0 and 9.9 ng/ml and were therefore considered to be passively exposed to tobacco smoke. The crude mean birth weight of infants of the women passively exposed to smoke was 107 gm lower than that of infants of unexposed women, and that difference remained after the application of a multivariate analysis that included the major known birth weight-associated covariates. These findings are consistent with a causal relationship between passive exposure to tobacco smoke and birth weight and suggest that the dose-response relationship may not be linear.