ATYPICAL BASAL-CELL HYPERPLASIA OF THE PROSTATE - IMMUNOPHENOTYPIC PROFILE AND PROPOSED CLASSIFICATION OF BASAL-CELL PROLIFERATIONS
ATYPICAL BASAL-CELL HYPERPLASIA OF THE PROSTATE - IMMUNOPHENOTYPIC PROFILE AND PROPOSED CLASSIFICATION OF BASAL-CELL PROLIFERATIONS
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DOI：
10.1097/00000478-199307000-00001
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发表时间：
1993-07-01
影响因子：
5.6
通讯作者：
BOSTWICK, DG
中科院分区：
文献类型：
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作者：
DEVARAJ, LT;BOSTWICK, DG
前列腺基底细胞增生的范围从局灶性基底细胞增生（BCH）到华丽腺样基底细胞瘤（ABCT）。我们回顾了36例基底细胞增殖，以评估这些病变的结构和细胞学谱，并在光镜下确定了四种不同的模式：BCH， 12例，包括2例间质硬化；非典型BCH伴核仁肿大8例；基底细胞腺瘤9例；ABCT 7例。对23例患者进行免疫组织化学评估，结果显示基底细胞具有基底细胞特异性高分子量角蛋白34betaE12的细胞质免疫反应性，但与BCA和ABCT相比，BCH的染色增加。除BCA和ABCT各2例外，所有病例均至少局部可见前列腺特异性抗原和前列腺酸性磷酸酶反应性。嗜铬粒蛋白、S-100蛋白和神经元特异性烯醇化酶反应性在所有病例中均罕见或阴性。36例中有18例的核核直径在非典型BCH（平均1.96 mum）中显著大于其他形式的基底细胞增殖（平均< 1.0 mum） （P < 0.05）。这些结果。基于光镜、免疫组织化学和形态测量结果，前列腺基底细胞增殖谱可分为四组：BCH、非典型BCH、BCA和ABCT。
Prostatic basal cell proliferations range from focal basal cell hyperplasia (BCH) to florid adenoid basal cell tumor (ABCT). We reviewed 36 cases of basal cell proliferation to evaluate the architectural and cytologic spectrum of these lesions and identified four distinct patterns by light microscopy: BCH, 12 cases, including two cases with stromal sclerosis; atypical BCH with nucleolomegaly, eight cases; basal cell adenoma (BCA), nine cases; and ABCT, seven cases. Twenty-three cases were evaluated immunohistochemically, and all displayed cytoplasmic immunoreactivity in basal cells with basal-cell-specific high-molecular-weight keratin 34betaE12 but with increased staining in BCH compared with that in BCA and ABCT. Prostate-specific antigen and prostatic acid phosphatase reactivity were seen at least focally in all cases except two cases each of BCA and ABCT. Chromogranin, S-100 protein, and neuron-specific enolase reactivity were rare or negative in all cases. Nucleolar diameter, measured in 18 of the 36 cases, was significantly greater in atypical BCH (mean, 1.96 mum) than in other forms of basal cell proliferation (mean, < 1.0 mum) (P < 0.05). These results. indicate that on the basis of light microscopic, immunohistochemical, and morphometric findings, the spectrum of basal cell proliferations in the prostate can be separated into four distinct groups: BCH, atypical BCH, BCA, and ABCT.