ALEUTIAN DISEASE IN FERRETS
ALEUTIAN DISEASE IN FERRETS
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DOI：
10.1128/iai.36.1.379-386.1982
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发表时间：
1982-01-01
影响因子：
3.1
通讯作者：
LARSEN, AE
中科院分区：
文献类型：
--
作者：
PORTER, HG;PORTER, DD;LARSEN, AE
当 32 只无抗体的雪貂接种对水貂具有高毒力的阿留申病病毒 (ADV) Utah-1 株时，大多数在感染后 15 天开始产生 ADV 抗体，但抗体滴度远低于水貂中的抗体滴度。仅在实验感染后 4-10 天，使用雪貂脾脏和淋巴结匀浆，在猫肾肿瘤 CRFK 细胞培养中证明了相对少量的 ADV，但通过水貂接种显示了 180 天的低水平病毒持续存在。接种ADV Utah-1株的雪貂没有出现升高的γ-球蛋白水平，但确实具有轻微的组织损伤。在 214 只近期怀孕的雌性雪貂中，42%（约 1 岁）被发现具有 ADV 抗体。用ADV抗体对雪貂的血清蛋白进行的分析表明，它们的血清γ-球蛋白有显着但轻微的升高。证明了雪貂 ADV 品系通过接种脾匀浆可在雪貂之间连续传播；其中一些雪貂出现肝脏病变。接种雪貂ADV的水貂产生了抗体，但没有出现高丙种球蛋白血症或组织病变。尽管雪貂和水貂的ADV病毒株都能在雪貂体内复制并持续存在，但它们不会引起密切相关的水貂中常见的严重疾病。水貂和雪貂 ADV 毒株在生物学上似乎是不同的。
When 32 antibody-free ferrets were inoculated with the highly mink-virulent Utah-1 strain of Aleutian disease virus (ADV), most developed ADV antibody starting 15 days after infection, but the antibody titers were much lower than those seen in mink. Relatively small amounts of ADV were demonstrated in feline kidney neoplastic CRFK cell culture, using ferret spleen and lymph node homogenates only 4-10 days after experimental infection, but low-level viral persistence for 180 days was shown by mink inoculation. The ferrets inoculated with the Utah-1 strain of ADV did not develop elevated .gamma.-globulin levels, but did have mild tissue lesions. Of a group of 214, 42% (.apprx. 1 yr old) recently pregnant, female ferrets were found to have antibody to ADV. An analysis of the serum proteins of the ferrets with ADV antibody showed that they had a significant, but mild, elevation of their serum .gamma.-globulin. Serial ferret-to-ferret transmission of a ferret strain of ADV by inoculation of spleen homogenates was demonstrated; some of these ferrets developed liver lesions. Mink inoculated with ferret ADV made antibody, but did not develop hypergammaglobulinemia or tissue lesions. Although both ferret and mink strains of ADV replicate and persist in the ferret, they fail to cause severe disease of the type usually seen in the closely related mink. Mink and ferret ADV strains appear to be biologically distinct.