Gonad morphogenesis and distal tip cell migration in the Caenorhabditis elegans hermaphrodite.
Gonad morphogenesis and distal tip cell migration in the Caenorhabditis elegans hermaphrodite.
复制标题
DOI：
10.1002/wdev.45
复制
发表时间：
2012-07
影响因子：
--
通讯作者：
Schwarzbauer, Jean E.
中科院分区：
文献类型：
--
作者：
Wong, Ming-Ching;Schwarzbauer, Jean E.
细胞迁移和形态发生是组织发育和器官发生的关键事件。在秀丽隐杆线虫中，远端尖端细胞的迁移路径决定了雌雄同体性腺的形态。末梢细胞经过一系列的迁移过程，形成性腺。从编码细胞外基质成分和修饰因子的基因到信号蛋白和转录调节因子，各种各样的基因已被确定为这一过程的关键。细胞外和跨膜蛋白功能与细胞内通路之间的联系对于远端尖端细胞迁移至关重要，这些信息的整合控制着性腺的形态发生，并决定性腺的大小和形状。
Cell migration and morphogenesis are key events in tissue development and organogenesis. In Caenorhabditis elegans, the migratory path of the distal tip cells determines the morphology of the hermaphroditic gonad. The distal tip cells undergo a series of migratory phases interspersed with turns to form the gonad. A wide variety of genes have been identified as crucial to this process, from genes that encode components and modifiers of the extracellular matrix to signaling proteins and transcriptional regulators. The connections between extracellular and transmembrane protein functions and intracellular pathways are essential for distal tip cell migration, and the integration of this information governs gonad morphogenesis and determines gonad size and shape.