Risk and association of HLA with oxcarbazepine-induced cutaneous adverse reactions in Asians
Risk and association of HLA with oxcarbazepine-induced cutaneous adverse reactions in Asians
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DOI：
10.1212/wnl.0000000000003453
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发表时间：
2017-01-03
期刊：
影响因子：
9.9
通讯作者：
Chung, Wen-Hung
中科院分区：
文献类型：
--
作者：
Chen, Chun-Bing;Hsiao, Yi-Hsin;Chung, Wen-Hung
目的：探讨奥卡西平引起皮肤不良反应的风险和遗传相关性（OXC-cADR），包括Stevens-Johnson综合征/中毒性表皮坏死松解症（SJS/TEN），在亚洲人群中（中文和泰文）。我们前瞻性招募了2006年至2014年在台湾和泰国发生OXC-cADR的患者，并分析了临床病程、潜伏期、药物剂量、器官受累、并发症，and mortality.我们还研究了OXC-cADR患者的HLA-B*15：02和HLA-A*31：01携带率，并与OXC耐受对照组进行了比较。OXC-SJS/TEN的发生率与卡马西平（CBZ）诱导的SJS/TEN进行了比较，根据全国人口数据集从台湾全民健康保险研究Database.Results：我们招募了50例OXC-cADR患者，包括20 OXC-SJS/TEN和6例药物反应与嗜酸性粒细胞增多症和全身症状，中国患者来自台湾和泰国患者来自泰国。OXC-cADR的临床严重程度较低，包括有限的皮肤脱落（所有
Objective: To investigate the risk and genetic association of oxcarbazepine-induced cutaneous adverse reactions (OXC-cADRs), including Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), in Asian populations (Chinese and Thai).Methods: We prospectively enrolled patients with OXC-cADRs in Taiwan and Thailand from 2006 to 2014, and analyzed the clinical course, latent period, drug dosage, organ involvement, complications, and mortality. We also investigated the carrier rate of HLA-B*15:02 and HLA-A*31:01 of patients with OXC-cADRs and compared to OXC-tolerant controls. The incidence of OXC-SJS/TEN was compared with carbamazepine (CBZ)-induced SJS/TEN according to the nationwide population dataset from the Taiwan National Health Insurance Research Database.Results: We enrolled 50 patients with OXC-cADRs, including 20 OXC-SJS/TEN and 6 drug reaction with eosinophilia and systemic symptoms, of Chinese patients from Taiwan and Thai patients from Thailand. OXC-cADRs presented with less clinical severity including limited skin detachment (all