Influence of repeated administration of cholecystokinin and secretin on the pancreas of the rat.
Influence of repeated administration of cholecystokinin and secretin on the pancreas of the rat.
复制标题
重复给予胆囊收缩素和促胰液素对大鼠胰腺的影响。
DOI：
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发表时间：
1978
影响因子：
1.9
通讯作者：
K. Wormsley
中科院分区：
文献类型：
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作者：
U. Fölsch;K. Winckler;K. Wormsley
在长达3周的时间内重复注射胆囊收缩素（CCK）可显著增加大鼠胰腺的重量。这与每单位重量DNA的蛋白质量增加有关，表明腺泡细胞肥大，与胰腺DNA总量增加有关，表明腺体额外增生。CCK还可使胰腺淀粉酶和胰蛋白酶含量增加，而脂肪酶含量无明显变化。CCK处理的大鼠中两种酶的分泌速率增加，尽管似乎单个胰腺腺泡细胞的功能能力没有增加。CCK注射对胰腺的胰岛素含量或对腮腺的组成没有影响。重复注射本研究所用剂量的促胰液素对胰腺没有影响。
Repeated injections of cholecystokinin (CCK) during a period of up to 3 weeks significantly increased the weight of the pancreas in rats. This was associated with an increase in the amount of protein per unit weight of DNA, suggesting hypertrophy of the acinar cells, and with increase in the total amount of pancreatic DNA, indicating additional hyperplasia of the gland. CCK administration also increased the pancreatic content of amylase and trypsin, but the content of lipase remained unchanged. The rate of secretion of the two enzymes increased in the CCK-treated rats, although it appeared that the functional capacity of the individual pancreatic acinar cells was not increased. CCK injections had no effect on the insulin content of the pancreas or on the composition of the partoid glands. Repeated injections of secretin in the doses used in this study had no effect on the pancreas.