Morphological evaluation of cranial and maxillary shape differences of the brachymorphic mouse with spontaneous malocclusion using three-dimensional micro-computed tomography
Morphological evaluation of cranial and maxillary shape differences of the brachymorphic mouse with spontaneous malocclusion using three-dimensional micro-computed tomography
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三维显微计算机断层扫描对自发性错牙合短形小鼠颅骨和上颌骨形状差异的形态学评估
DOI：
10.1111/j.1601-6343.2011.01513.x
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发表时间：
2011
影响因子：
3.1
通讯作者：
et al.
中科院分区：
文献类型：
--
作者：
F Saito;et al.
引用本文：Saito F，Kajii TS，Sugawa-Kato Y，Tsukamoto Y，Arai Y，Hirabayashi Y，Fujimori O，Iida J：
形态评价自发性错牙合畸形小鼠颅骨和上颌骨的形态差异。作者 -Saito F，Kajii TS，Sugawa-Kato Y，Tsukamoto Y，Arai Y，Hirabayashi Y，Fujimori O，Iida JJ目的：本研究的目的是利用三维(3D)图像确定BALB/c-BM/BM小鼠是否存在明显的颅颌畸形。材料与方法 -30只雌性小鼠分为三组：对照组(BALB/c小鼠，n = 10只)、正常对照组(BALB/c-BM/bm小鼠，n = 10只)。MAL组(BALB/c-BM/BM错牙合小鼠，n = 10只)。选择颅骨内9个点，利用CT三维图像测量颅骨的横向距离和前后距离。结果 -正常组和MAL组颅骨后、上颌区横径和前后径均明显短于对照组。MAL组的鼻中隔明显短于正常组。形态测量和3D图像叠加显示MAL组小鼠前颅骨和上颌骨发生侧移。结论 -3DMicro-CT图像显示BALB/c-BM/bm小鼠颅骨和上颌骨的前后长度和后横向宽度明显小于BALB/c小鼠。从数量和形态上看，BALB/c-BM/bm小鼠由于上颌骨和鼻骨的侧偏而表现出自发性的横向反牙合。
To cite this article:Saito F, Kajii TS, Sugawara‐Kato Y, Tsukamoto Y, Arai Y, Hirabayashi Y, Fujimori O, Iida J:
Morphological evaluation of cranial and maxillary shape differences of the brachymorphic mouse with spontaneous malocclusion using three‐dimensional micro‐computed tomographyOrthod Craniofac Res2011;14:100–106Structured AbstractAuthors –Saito F, Kajii TS, Sugawara‐Kato Y, Tsukamoto Y, Arai Y, Hirabayashi Y, Fujimori O, Iida JObjectives –The aim of this study was to determine whether significant cranial and maxillary deformity exists in BALB/c‐bm/bm(brachymorphism) mouse with spontaneous malocclusion using three‐dimensional (3D) images.Materials and Methods –Thirty female mice were divided into the following three groups: control group (BALB/c mice, n = 10), Norm group (BALB/c‐bm/bmmice with normal occlusion, n = 10), and Mal group (BALB/c‐bm/bmmice with malocclusion, n = 10). Nine points in the skull were selected, and transverse and antero‐posterior distances were measured using three‐dimensional images of micro‐computed tomography (CT). Moreover, 3D images were superimposed at the median plane to visualize the skull shape asymmetry.Results –The transverse distances at the posterior cranial and maxillary region and the antero‐posterior distances in the Norm and Mal groups were significantly shorter than those in the control group. The nasal septum of the Mal group was significantly shorter than that of the Norm group. Morphological measurements and superimposed 3D images showed that lateral deviation occurred at the anterior cranial and maxillary region in the Mal group.Conclusion –The 3D micro‐CT images revealed that the antero‐posterior length and posterior transverse width at the cranium and maxilla in BALB/c‐bm/bmmice were significantly smaller than those in BALB/c mice. It was quantitatively and morphologically clear that BALB/c‐bm/bmmice show a spontaneous transverse crossbite owing to lateral deviation of the maxilla and nasal bone.