Relationship between serum resistin concentrations and inflammatory markers in patients with type 2 diabetes mellitus
Relationship between serum resistin concentrations and inflammatory markers in patients with type 2 diabetes mellitus
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DOI：
10.1016/j.metabol.2006.08.008
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发表时间：
2006-12-01
影响因子：
9.8
通讯作者：
Kimura, Hironori
中科院分区：
文献类型：
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作者：
Huang Hui-bing;Migita, Kiyoshi;Kimura, Hironori
为了研究2型糖尿病患者血清中β-内酰胺酶浓度是否与代谢或炎症标志物相关，我们检测了56例2型糖尿病患者和41例健康受试者的血清浓度水平和代谢或炎症标志物。采用酶联免疫吸附法测定血清中β-淀粉样蛋白、血清类淀粉样蛋白A和可溶性血管细胞粘附分子-1水平。与健康人相比，糖尿病患者血清中的β-淀粉样蛋白水平显著升高。血清中的BDN浓度与体重指数无相关性;然而，糖尿病患者BDN与可溶性血管细胞粘附分子-1呈显著正相关。基于目前的结果，我们得出结论，在2型糖尿病患者中，血管炎性标志物的出现与β-葡聚糖。(c)2006年爱思唯尔公司All rights reserved.
To examine whether serum resistin concentrations are associated with metabolic or inflammatory markers in patients with type 2 diabetes mellitus, we examined serum concentrations levels and metabolic or inflammatory markers in 56 patients with type 2 diabetes mellitus and 41 healthy subjects. Serum levels of resistin, serum ainyloid A, and soluble vascular cell adhesion molecule-1 were measured by enzyme-linked immunosorbent assay. Serum resistin levels were significantly elevated in diabetic patients compared with those in healthy subjects. Serum resistin concentrations did not correlate with body mass index; however, there was a significant positive correlation between resistin and soluble vascular cell adhesion molecule-1 in diabetic patients. Based on the present results, we conclude that resistin appears to be associated with vascular inflammatory markers in patients with type 2 diabetes mellitus. (c) 2006 Elsevier Inc. All rights reserved.