IMPAIRMENT OF THYMUS-DEPENDENT IMMUNE FUNCTIONS BY EXPOSURE OF DEVELOPING IMMUNE SYSTEM TO 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN (TCDD)
IMPAIRMENT OF THYMUS-DEPENDENT IMMUNE FUNCTIONS BY EXPOSURE OF DEVELOPING IMMUNE SYSTEM TO 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN (TCDD)
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DOI：
10.1080/15287397709529578
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发表时间：
1977-01-01
期刊：
影响因子：
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通讯作者：
MOORE, JA
中科院分区：
文献类型：
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作者：
FAITH, RE;MOORE, JA
研究了TCDD暴露对F344大鼠免疫系统发育的影响。胎鼠和新生大鼠通过母体给药（5 .mu）暴露于TCDD。g/kg)，分别于妊娠第18天和出生后第0、7和14天（ⅰ组）。另一组新生大鼠仅在出生后第0、7和14天通过母体给药暴露于TCDD （II组）。在145日龄前，ⅰ组的体重和胸腺/体重比均受到抑制，而ⅱ组仅在39日龄前受到抑制。研究细胞免疫和体液免疫功能参数。TCDD抑制细胞免疫功能，但不影响体液免疫功能。T（胸腺源性）细胞功能的抑制是选择性的，因为辅助细胞功能不受抑制。
The effects of TCDD exposure on the developing immune system were investigated in F344 rats. Fetal and neonatal rats were exposed to TCDD through maternal dosing (5 .mu.g/kg) on day 18 of gestation and on days 0, 7 and 14 of postnatal life (group I). Another group of neonatal rats was exposed to TCDD through maternal dosing on days 0, 7 and 14 of postnatal life only (group II). Body weights and thymus/body weight ratios were suppressed up to 145 days of age in group I, but only up to 39 days of age in group II. Parameters of cell-mediated and humoral immune function were investigated. TCDD suppressed cellmediated immune function without affecting humoral immune function. Suppression of T [thymus derived]-cell function was selective in that helper cell function was not suppressed.