Selective Synthesis of α,β‐Unsaturated Ketones by Dibutyltin Dimethoxide Catalyzed Condensation of Aldehydes with Alkenyl Trichloroacetates.
Selective Synthesis of α,β‐Unsaturated Ketones by Dibutyltin Dimethoxide Catalyzed Condensation of Aldehydes with Alkenyl Trichloroacetates.
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DOI：
10.1002/chin.200510090
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发表时间：
2005-03
期刊：
影响因子：
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通讯作者：
A. Yanagisawa;Riku Goudu;T. Arai
中科院分区：
文献类型：
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作者：
A. Yanagisawa;Riku Goudu;T. Arai
以二丁基二甲醇锡为催化剂，三氯乙酸烯酯与醛在甲醇存在下进行缩合反应，立体选择性地合成了多种α，β-不饱和酮，产率高达94%。该方法在碱催化剂的温和性和产物选择性方面上级经典的施密特缩合。
Various α,β-unsaturated ketones were stereoselectively synthesized in high yields up to 94% by a condensation reaction between alkenyl trichloroacetates and aldehydes using dibutyltin dimethoxide as a catalyst in the presence of methanol. This process is superior to the classical Claisen−Schmidt condensation with respect to mildness of the base catalyst and product selectivity.