The angiotensin II type 1 receptor gene polymorphism is associated with coronary artery vasoconstriction
The angiotensin II type 1 receptor gene polymorphism is associated with coronary artery vasoconstriction
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DOI：
10.1016/s0735-1097(96)00535-9
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发表时间：
1997-03-01
影响因子：
24
通讯作者：
Bertrand, ME
中科院分区：
文献类型：
--
作者：
Amant, C;Hamon, M;Bertrand, ME
目标.本研究旨在评估血管紧张素转换酶（ACE）和血管紧张素II 1型（AT 1）受体基因多态性对人类冠状动脉vasomotion.Background冠状动脉vasomotion异常在冠状动脉粥样硬化的临床表现中发挥作用的潜在关联。肾素-血管紧张素系统的组分是血管紧张素的重要决定因素，而且，流行病学证据表明这些组分参与冠状动脉疾病的发病机制。事实上，ACE和AT 1受体基因的两种遗传多态性与心肌梗死的发生协同相关。这些基因多态性对心肌梗死风险的影响可能至少部分与冠状动脉血管运动的有害作用有关。我们研究了静脉注射马来酸甲基麦角新碱后血管造影正常的人冠状动脉的反应，甲基麦角新碱是一种强效的血管收缩剂，其作用已在冠状动脉疾病的各个方面进行了探索。我们对140例冠状动脉正常患者的ACE和AT 1受体基因型进行了分析，并用定量冠状动脉造影术评估了冠状动脉血管运动。未检测到ACE基因多态性的影响。相反，携带AT 1受体CC基因型的患者（n = 13）远端冠状动脉血管收缩显著更大（p < 0.009）。AT 1受体基因多态性与人类冠状动脉血管运动相关(C)1997年，美国心脏病学会。
Objectives. This study sought to assess the potential association of the angiotensin-converting enzyme (ACE) and angiotensin II type 1 (AT1) receptor gene polymorphisms on coronary vasomotion in humans.Background Abnormal coronary vasomotion plays a role in the clinical expression of coronary atherosclerosis. The components of the renin-angiotensin system are important determinants of vasomotor tone, Furthermore, epidemiologic evidence suggests that these components are involved in the pathogenesis of coronary artery disease. Indeed, two genetic polymorphisms of the ACE and AT1 receptor genes were synergistically associated with the occurrence of myocardial infarction. The influence of these genetic polymorphisms on the risk of myocardial infarction may be related, at least in part, to a deleterious effect on coronary vasomotion.Methods. We studied the response of angiographically normal human coronary arteries after intravenous injection of methylergonovine maleate, a potent vasoconstrictor whose effects have been previously explored in various aspects of coronary artery disease. We characterized the ACE and AT1 receptor genotypes in a consecutive series of 140 patients with normal coronary arteries, Coronary vasomotion was assessed with quantitative coronary angiography.Results. No effect of the ACE gene polymorphism was detected. Conversely, the patients carrying the AT1 receptor CC genotype (n = 13) had significantly greater vasoconstriction in distal coronary vessels (p < 0.009).Conclusions. The AT1 receptor gene polymorphism is associated with coronary vasomotion in humans. (C) 1997 by the American College of Cardiology.