Solitary fibrous tumor of the soft tissue. An immunohistochemical and ultrastructural study.
Solitary fibrous tumor of the soft tissue. An immunohistochemical and ultrastructural study.
复制标题
软组织孤立性纤维瘤。
DOI：
10.1093/ajcp/106.3.325
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发表时间：
1996
影响因子：
3.5
通讯作者：
T. Sano
中科院分区：
文献类型：
--
作者：
T. Hasegawa;T. Hirose;K. Seki;Peng;T. Sano
孤立性纤维瘤是一种罕见的梭形细胞肿瘤的成人，通常发生在胸膜，最近在其他地区的报告。作者描述了三例成人孤立性纤维性肿瘤，发生在躯体软组织中的局限性肿块，包括手臂，背部和腹部。在组织学上，它们的特征是由厚的胶原带分隔的梭形细胞增殖和显著的血管分布，通常显示血管外皮细胞瘤样模式。梭形细胞有丝分裂少，核分裂少，具有多种生长方式，包括故事状、束状、人字形和栅栏状核。波形蛋白和CD 34免疫反应在所有肿瘤的许多梭形细胞中观察到。2例具有成纤维细胞和肌成纤维细胞的超微结构特征。孤立性纤维肿瘤似乎代表了不同的间叶肿瘤，需要我们确定其不寻常的位置以外的胸膜，并熟悉其组织学表现，以达到正确的诊断。
Solitary fibrous tumor is a rare spindle cell neoplasm of adults that usually arises in the pleura, recently reported in other locations. The authors describe three cases of solitary fibrous tumors in adults that occurred as circumscribed masses in the somatic soft tissue, including the arm, back, and abdomen. Histologically, they were characterized by a proliferation of spindle cells separated by thick bands of collagen and prominent vascularity often showing a hemangiopericytoma-like pattern. The spindle cells, having low mitotic figures and little nuclear atypicality, exhibited a variety of growth patterns, including storiform, fascicular and herringbone, and nuclear palisading. Vimentin and CD34 immunoreactivities were observed in many spindle cells of all tumors. They had ultrastructural features of fibroblast and myofibroblast in two cases examined. Solitary fibrous tumors seem to represent distinct mesenchymal neoplasms that require us to identify their unusual location other than the pleura and be familiar with their histologic appearances for arriving at the correct diagnosis.