Helicobacter pylori dupA and gastric acid secretion are negatively associated with gastric cancer development
Helicobacter pylori dupA and gastric acid secretion are negatively associated with gastric cancer development
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DOI：
10.1099/jmm.0.021816-0
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发表时间：
2010-12-01
影响因子：
3
通讯作者：
Chayama, Kazuaki
中科院分区：
文献类型：
--
作者：
Imagawa, Shinobu;Ito, Masanori;Chayama, Kazuaki
很少有报道用长期随访研究描述消化性溃疡患者的癌症患病率。我们对日本消化性溃疡患者进行了一项长期回顾性队列研究，并评估了胃癌（GCa）发生的危险因素。共招募了136例1975年至1983年诊断为消化性溃疡的患者。入组时69例胃溃疡（GU）和67例十二指肠溃疡（DU）患者，平均随访14 4年在与广岛县的肿瘤登记数据库匹配后，对GCa进行了调查。对56例胃活检标本进行包埋，对40例初诊消化性溃疡患者进行了胃酸分泌和基础酸排出量（BAO）测定，68例进行了最大酸排出量测定，24例患者进行了GCa检测GU组GCa检出率显著高于DU组（log-rank检验P
Few reports have described the cancer prevalence of peptic ulcer patients with long-term followup studies We have conducted a long-term retrospective cohort study of Japanese peptic ulcer patients and evaluated the risk factors for the occurrence of gastric cancer (GCa) A total of 136 patients diagnosed with peptic ulcers from 1975 to 1983 were enrolled These 136 cases [102 males and 34 females, 69 gastric ulcer (GU) and 67 duodenal ulcer (DU) patients at the time of enrolment, mean follow-up period of 14 4 years (range 1-30 years)] after being matched with a tumour registry database in Hiroshima prefecture were surveyed for GCa We investigated Helicobacter pylori duodenal ulcer promoter gene A (dupA) using paraffin-embedded gastric biopsy specimens in 56 cases Gastric acid secretion and basal acid output (BAO) in 40 cases, and maximal acid output in 68 cases, had been measured at first diagnosis of peptic ulcers GCa was detected in 24 patients (17 with GU, 7 with DU) during the follow-up The prevalence of GCa was significantly higher in GU patients than in DU patients (log-rank test P