Effect of allogeneic blood transfusion on levels of IL-6 and sIL-R2 in peripheral blood of children with acute lymphocytic leukemia.
Effect of allogeneic blood transfusion on levels of IL-6 and sIL-R2 in peripheral blood of children with acute lymphocytic leukemia.
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DOI：
10.3892/ol.2018.8760
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发表时间：
2018-07
期刊：
影响因子：
2.9
通讯作者：
Zhao F
中科院分区：
文献类型：
--
作者：
Zhao H;Zhou H;Cao Q;Wang C;Bai J;Lv P;Zhao F
探讨异基因输血对急性淋巴细胞白血病（ALL）患儿外周血白细胞介素6（IL-6）和可溶性白细胞介素2受体（sIL-2 R）表达的影响。选取2014年6月至2017年1月在南方医院住院的91例ALL患儿作为研究组。将患者随机分为输血组（n=38）和非输血组（n=53）。此外，还选择了2014年6月至2017年1月期间的64名健康儿童作为对照组。异基因输血组患者输注红细胞悬液和机采血小板，不输血组患者不输注。分别于输血前、输血后4、8、12周采集外周静脉血制备血清。采用酶联免疫吸附法（ELISA）测定血清IL-6和sIL-2 R水平。输血前研究组血清IL-6和sIL-2 R水平显著低于对照组（p<0.05），而输血组与未输血组比较，IL-6和sIL-2 R水平无显著性差异。输血后，非输血组IL-6和sIL-2 R水平稳定12周，而异体输血组IL-6和sIL-2 R水平显著升高。结果表明，输入异基因血的ALL患者血清IL-6和sIL-2 R水平升高，导致抗体产生减少，细胞免疫功能下降。患者免疫力低下，应注意病原体感染的预防。
Effect of allogeneic blood transfusion on the expression of interleukin-6 (IL-6) and soluble interleukin-2 receptor (sIL-2R) in peripheral blood of children with acute lymphoblastic leukemia (ALL) was investigated. A total of 91 ALL children admitted to Nanfang Hospital from June 2014 to January 2017 were selected as the study group. Patients were randomly divided into allogeneic blood transfusion group (n=38) and non-transfusion group (n=53). In addition, a total of 64 healthy children were also selected from June 2014 to January 2017 as the control group. Patients in allogeneic blood transfusion group were transfused with red blood cell suspension and machine-collected platelets, while patients in non-transfusion group were not treated with blood transfusion. Peripheral venous blood was collected before and at 4, 8 and 12 weeks after blood transfusion to prepare serum. Serum IL-6 and sIL-2R levels were measured by enzyme-linked immunosorbent assay (ELISA). Before transfusion, serum levels of IL-6 and sIL-2R were significantly lower in the study group than those in control group (p<0.05), and no significant differences in serum levels of IL-6 and sIL-2R were found between the allogeneic blood transfusion and non-transfusion group. After transfusion, serum levels of IL-6 and sIL-2R were stable for 12 weeks in the non-transfusion group, while IL-6 and sIL-2R levels were significantly increased in the allogeneic blood transfusion group. The results showed that serum level of IL-6 and sIL-2R was increased in ALL patients with allogeneic blood transfusion, which resulted in reduced antibody production and decreased cellular immunity. The patients had low immunity, and attention should be paid on the pathogen infection prevention.
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影响因子：
8.8
作者：
Izbicki, G;Rudensky, B;Hersch, M
通讯作者：
Hersch, M
影响因子：
168.9
作者：
Pui, CH;Gaynon, PS;Camitta, B
通讯作者：
Camitta, B
DOI：
10.1007/s00432-004-0600-9
发表时间：
2005-02-01
影响因子：
3.6
作者：
Goto, H;Tsurumi, H;Moriwaki, H
通讯作者：
Moriwaki, H
影响因子：
3.7
作者：
Yoshida N;Oda M;Kuroda Y;Katayama Y;Okikawa Y;Masunari T;Fujiwara M;Nishisaka T;Sasaki N;Sadahira Y;Mihara K;Asaoku H;Matsui H;Seto M;Kimura A;Arihiro K;Sakai A
通讯作者：
Sakai A
影响因子：
45.3
作者：
Katsuya, Hiroo;Yamanaka, Takeharu;Tamura, Kazuo
通讯作者：
Tamura, Kazuo