Primary lymphoma of the lacrimal sac:: an EORTC ophthalmic oncology task force study
Primary lymphoma of the lacrimal sac:: an EORTC ophthalmic oncology task force study
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DOI：
10.1136/bjo.2006.090589
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发表时间：
2006-08-01
影响因子：
4.1
通讯作者：
Heegaard, S.
中科院分区：
文献类型：
--
作者：
Sjo, L. D.;Ralfkiaer, E.;Heegaard, S.
目的：明确以白人为主的原发泪囊淋巴瘤的临床和组织病理学特征。方法：从欧洲癌症研究和治疗组织(EORTC)和欧洲眼科病理学会(EOPS)的眼科肿瘤工作组成员那里获得泪囊淋巴瘤的标本和随访数据。标本用苏木素和伊红染色，并应用免疫组织化学方法对抗白细胞抗原。根据世界卫生组织的分类系统，由五名经验丰富的病理学家达成共识，得出诊断结果。结果：15例原发泪囊淋巴瘤中，弥漫性大B细胞淋巴瘤(DLBCL)5例(33%)，粘膜相关淋巴组织结外边缘区B细胞淋巴瘤(MALT)5例(33%)，过渡性MALT淋巴瘤3例，未分类B细胞淋巴瘤2例。其中9名患者为女性，确诊时的中位年龄为71岁(范围为45-95岁)。最常见的症状是溢泪(85%)、泪囊区肿胀(79%)和泪囊炎(21%)。除1例患者外，其余患者均为I期，9例患者中有3例发生全身扩散(33%)。5年生存率为65%。结论：DLBCL和MALT淋巴瘤在泪囊中同样常见，而眶周和/或眶周区域则以MALT淋巴瘤为主。
Aim: To define the clinical and histopathological characteristics of primary lacrimal sac lymphoma in a predominantly white population.Methods: Specimens of lacrimal sac lymphoma and follow up data were solicited from members of the Ophthalmic Oncology Task Force of the European Organization for Research and Treatment of Cancer (EORTC) and the European Ophthalmic Pathology Society (EOPS). Specimens were stained with haematoxylin and eosin and an immunohistochemical panel against leucocyte antigens was applied. Diagnosis was reached by consensus of five experienced pathologists according to the World Health Organization classification system. The histopathological findings were correlated with the clinical data.Results: Of 15 primary lacrimal sac lymphomas, five (33%) were diffuse large B cell lymphoma (DLBCL), five (33%) were extranodal marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT lymphoma), three were classified as "transitional MALT lymphoma," being in transition from MALT lymphoma to DLBCL, and two were unclassified B cell lymphomas. Nine of the patients were female, and the median age at the time of diagnosis was 71 years (range 45-95 years). The most frequent presenting symptoms were epiphora (85%), swelling in the region of the lacrimal sac (79%), and dacryocystitis (21%). All but one patient presented in stage I. Systemic spread occurred in three of nine patients (33%). The 5 year overall survival was 65%.Conclusions: DLBCL and MALT lymphoma are equally common in the lacrimal sac in contrast with the remaining periorbital and/or orbital region where MALT lymphoma predominates.