2,2,2-Trichloroethyl Aryldiazoacetates as Robust Reagents for the Enantioselective C-H Functionalization of Methyl Ethers
2,2,2-Trichloroethyl Aryldiazoacetates as Robust Reagents for the Enantioselective C-H Functionalization of Methyl Ethers
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DOI：
10.1021/ja5107404
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发表时间：
2014-12-24
影响因子：
15
通讯作者：
Davies, Huw M. L.
中科院分区：
文献类型：
--
作者：
Guptill, David M.;Davies, Huw M. L.
本文描述了一类新的试剂，通过C-H插入的方法，利用给体/受体取代的Rh(II)卡宾中间体进行C-H官能化。2，2，2-三氯乙基芳基和杂芳基重氮乙酸酯与三芳基环丙烷羧酸二氢钠催化剂Rh2(R-BPCP)4一起，实现了一系列具有较高位置选择性和对映体选择性的甲醚的对映选择性分子间C-H官能化。
A new class of reagents is described for C-H functionalization by means of C-H insertion using donor/acceptor-substituted rhodium(II) carbene intermediates. The 2,2,2-trichloroethyl aryl and heteroaryl diazoacetates, together with the dirhodium triarylcyclopropane carboxylate catalyst Rh2(R-BPCP)4, enabled the enantioselective intermolecular C-H functionalization of a range of methyl ethers with high levels of site selectivity and enantioselectivity.