Multivariate survival analysis of histological parameters and clinical presentation in canine cutaneous mast cell tumours
Multivariate survival analysis of histological parameters and clinical presentation in canine cutaneous mast cell tumours
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DOI：
10.1007/s11259-006-3427-9
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发表时间：
2007-04-01
影响因子：
2.2
通讯作者：
Paltrinieri, M.
中科院分区：
文献类型：
--
作者：
Preziosi, R.;Sarli, G.;Paltrinieri, M.
Patnaik组织学分级是预测肥大细胞肿瘤长期行为的好方法，但它受到主观观察者间差异和肿瘤内异质性的影响。本研究评估了用于制定Patnaik分级的每一个组织病理学参数的预后，并测试了它们是否具有不同的预后敏感性，从而揭示了哪些参数可以被认为在预测肿瘤复发和患者生存方面更有用。临床表现(单个或多个肿瘤)也被认为是可能的预后因素。结果表明，单独的组织学标准和多种表现相结合可能对预测肥大细胞瘤的预后有价值。其中，侵袭性(Beta1.85；标准差1.15)和有丝分裂数(Beta3.01；标准误1.18)对预后有高度的预测意义(X~2=15.52，自由度=6，p=0.016)，可以作为可靠的预后指标，避免了细胞分化、核形态和肿瘤类型等更多的主观参数。
The Patnaik histological grade is a good method for the prediction of long-term mast cell tumour behaviour but it is influenced by subjective inter-observer variations and intratumoral heterogeneity. The present study evaluated each of the histopathological parameters used to formulate Patnaik's grade in terms of prognosis and tested whether they have a different prognostic sensitivity, thereby disclosing which could be considered more useful in the prediction of tumour recurrence and patient survival. Clinical presentation (single or multiple tumours) was also considered as possible prognostic factor. The results demonstrated that individual histological criteria together with multiple presentation may be of value in predicting the outcome of mast cell tumours. Among these, invasiveness (beta 1.85; standard error 1.15) and the number of mitotic figures (beta 3.01; standard error 1.18) showed high prognostic significance (Cox proportional hazard regression for censored data ; chi-squared = 15.52, degree of freedom = 6, p = 0.016) and could serve as reliable prognostic indicators avoiding more subjective parameters such as cellular differentiation, nuclear morphology and tumoural pattern.