Rapid weight gain during infancy and obesity in young adulthood in a cohort of African Americans
Rapid weight gain during infancy and obesity in young adulthood in a cohort of African Americans
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DOI：
10.1093/ajcn/77.6.1374
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发表时间：
2003-06-01
影响因子：
7.1
通讯作者：
Stallings, VA
中科院分区：
文献类型：
--
作者：
Stettler, N;Kumanyika, SK;Stallings, VA
背景：肥胖在美国日益增多，基于证据的预防是一项公共卫生优先事项，应针对明确的风险因素和关键时期。目的：我们测试了婴儿早期体重快速增加与非洲裔美国年轻人（肥胖风险增加的群体）肥胖相关的假设。设计：对 300 名足月出生的非洲裔美国人进行了从出生到 20 岁的跟踪调查。体重快速增加模式被定义为出生至 4 个月期间年龄别体重增加大于或等于 1 SD。 结果：约 29% 的受试者在婴儿期有体重快速增加模式； 8% 的人在 20 岁时肥胖[体重指数（以 kg/m(2) 为单位）大于或等于 30]。 20 岁时肥胖的三分之一可归因于生命最初 4 个月内体重快速增加。调整混杂因素后，婴儿早期体重快速增加的受试者更有可能在 20 岁时变得肥胖（比值比 = 5.22；95% CI：1.55，17.6；P = 0.008）。该结果通过结合体重指数和皮褶厚度得到证实（比值比 = 6.72；95% CI：1.93, 23.4；P = 0.003）。结论：本研究的结果提供了证据，表明婴儿早期体重快速增加的模式不仅与儿童期的肥胖有关，而且与成年早期的肥胖有关。我们认为婴儿早期是肥胖发生的关键时期。行动机制和预防策略需要进一步研究。
Background: Obesity is increasing in the United States, Evidence-based prevention is a public health priority and should target well-defined risk factors and critical periods.Objective: We tested the hypothesis that rapid weight gain during early infancy is associated with obesity in African American young adults, a group at increased risk of obesity.Design: A cohort of 300 African Americans born at full term was followed from birth to 20 y of age. A pattern of rapid weight gain was defined as an increase in weight-for-age greater than or equal to 1 SD between birth and 4 mo.Results: About 29% of subjects had a pattern of rapid weight gain during infancy; 8% were obese [body mass index (in kg/m(2)) greater than or equal to 30] at age 20 y. One-third of the obesity at age 20 y could be attributed to rapid weight gain in the first 4 mo of life. After adjustment for confounding factors, subjects with rapid weight gain during early infancy were more likely to become obese at age 20 y (odds ratio = 5.22; 95% CI: 1.55, 17.6; P = 0.008). The results were confirmed by using a combination of body mass index and skinfold thickness (odds ratio = 6.72; 95% CI: 1.93, 23.4; P = 0.003).Conclusions: The results of the present study provide evidence that a pattern of rapid weight gain during early infancy is associated with obesity not only in childhood but also in young adulthood. We propose that early infancy constitutes a critical period for the development of obesity. Mechanisms of action and prevention strategies require further investigation.