Degradation and Mechanical Behavior of Fish Gelatin/Polycaprolactone AC Electrospun Nanofibrous Meshes
Degradation and Mechanical Behavior of Fish Gelatin/Polycaprolactone AC Electrospun Nanofibrous Meshes
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DOI：
10.1002/mame.202300106
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发表时间：
2023-07
影响因子：
3.9
通讯作者：
Hannah A. Lacy;S. Nealy;A. Stanishevsky
中科院分区：
文献类型：
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作者：
Hannah A. Lacy;S. Nealy;A. Stanishevsky
随着生物聚合物纳米纤维在不同领域的应用日益广泛，对这些材料在生理环境中的表征也变得同样重要。本研究首次对高通量自由表面交变电场纺丝制备的鱼胶(FGEL)和聚己内酯(PCL)纳米纤维网进行了模拟体液(SBF)降解和拉伸力学分析。热交联型FGEL/PCL纳米纤维材料的孔隙率为84-96%，PCL含量高达60wt%，在SBF中14d的质量保留率可达88.4%。用傅里叶变换红外光谱分析了SBF降解过程中PCL结晶度和FGEL二级结构修饰的变化趋势。这种0.1-2.2 mm厚的多孔FGEL/PCL纳米纤维网在SBF中的拉伸测试显示，根据FGEL/PCL质量比的不同，极限拉伸强度、杨氏模量和断裂伸长率分别在60-105千帕、0.3-1.6兆帕和20-70%的范围内。结果表明，由难混溶的FGEL和PCL制备的FGEL/PCL纳米纤维材料可以适用于特定的生物医学应用，如皮肤支架、颅骨交叉韧带、关节软骨或血管组织修复。
With the increasing interest in biopolymer nanofibers for diverse applications, the characterization of these materials in the physiological environment has become of equal interest and importance. This study performs first‐time simulated body fluid (SBF) degradation and tensile mechanical analyses of blended fish gelatin (FGEL) and polycaprolactone (PCL) nanofibrous meshes prepared by a high‐throughput free‐surface alternating field electrospinning. The thermally crosslinked FGEL/PCL nanofibrous materials with 84–96% porosity and up to 60 wt% PCL fraction demonstrate mass retention up to 88.4% after 14 days in SBF. The trends in the PCL crystallinity and FGEL secondary structure modification during the SBF degradation are analyzed by Fourier transform infrared spectroscopy. Tensile tests of such porous, 0.1–2.2 mm thick FGEL/PCL nanofibrous meshes in SBF reveal the ultimate tensile strength, Young's modulus, and elongation at break within the ranges of 60–105 kPa, 0.3–1.6 MPa, and 20–70%, respectively, depending on the FGEL/PCL mass ratio. The results demonstrate that FGEL/PCL nanofibrous materials prepared from poorly miscible FGEL and PCL can be suitable for selected biomedical applications such as scaffolds for skin, cranial cruciate ligament, articular cartilage, or vascular tissue repair.