Wall Teichoic Acid-Dependent Adsorption of Staphylococcal Siphovirus and Myovirus
Wall Teichoic Acid-Dependent Adsorption of Staphylococcal Siphovirus and Myovirus
复制标题
葡萄球菌管病毒和肌病毒的壁磷壁酸依赖性吸附
作者：
Guoqing Xia;R. Corrigan;Volker Winstel;C. Goerke;A. Gründling;A. Peschel
摘要葡萄球菌与宿主细胞表面的分子相互作用目前还知之甚少。采用金黄色葡萄球菌磷壁酸突变体，我们表明，壁磷壁酸（WTA），但不是脂磷壁酸，作为葡萄球菌管蚜病毒和myovirus的受体，而只有管蚜病毒需要糖基化WTA。
ABSTRACT The molecular interactions between staphylococcal phages and host cell surfaces are poorly understood. Employing Staphylococcus aureus teichoic acid mutants, we demonstrate that wall teichoic acid (WTA), but not lipoteichoic acid, serves as a receptor for staphylococcal siphovirus and myovirus, while only the siphovirus requires glycosylated WTA.