Gender differences in pain modulation evoked by repeated injections of glutamate into the human trapezius muscle
Gender differences in pain modulation evoked by repeated injections of glutamate into the human trapezius muscle
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DOI：
10.1016/j.pain.2004.09.041
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发表时间：
2005-01-01
期刊：
影响因子：
7.4
通讯作者：
Arendt-Nielsen, L
中科院分区：
文献类型：
--
作者：
Ge, HY;Madeleine, P;Arendt-Nielsen, L
性别差异的疼痛习惯，时间总和，和压力痛觉过敏引起的谷氨酸重复注射到优势肌进行了研究。测定谷氨酸诱发的肌肉痛强度和压力痛阈值（PPT）。在健康和年龄匹配的男性和女性（各n = 14）中，在谷氨酸盐注射后，测量双侧阔肌（局部疼痛区域）和颈后外侧肌（牵涉疼痛区域）的PPT。间隔5分钟注射两次谷氨酸盐注射液（每次0.4 ml，2 M）。注射一次谷氨酸盐（0.4 ml，2 M）作为对照。男性（而非女性）认为第二次注射（最大疼痛强度）的疼痛程度显著低于第一次注射。雌性动物第二次注射的视觉模拟量表疼痛曲线下面积显著大于第一次注射。重复注射谷氨酸盐，但不是一次注射谷氨酸盐，显著降低了局部疼痛区域的PPT，没有显著的性别差异。在两种性别的对侧阔肌或双侧牵涉疼痛区均未观察到PPT变化。这些结果表明，一个效率较低的疼痛习惯和更大的敏感性，以发展的时间总和肌肉疼痛的女性，但不是在男性，可能是一个促成因素的颈肩痛的发病率较高的女性。此外，肌内注射谷氨酸引起的局部疼痛区域的PPT减少可能代表外周压力痛觉过敏的早期过程，这很可能是性别无关的。(C)2004年国际疼痛研究协会。Elsevier B.V.出版，保留所有权利。
Gender differences in pain habituation, temporal summation, and pressure hyperalgesia evoked by repeated injections of glutamate into the dominant trapezius muscle were investigated. The glutamate-evoked muscle pain intensity and pressure pain threshold (PPT) were assessed. The PPTs were measured bilaterally in the trapezius muscles (local pain area) and posterolateral neck muscles (referred pain area) after glutamate injection in healthy and age-matched males and females (each n = 14). Two glutamate injections (0.4 ml, 2 M each) were injected with an interval of 5 min. One injection of glutamate (0.4 ml, 2 M) served as a control. Males, but not females, rated the second injection (maximal pain intensity) significantly less painful than the first injection. The area under the visual analogue scale pain curve of the second injection was significantly larger than the first injection in females. Repeated glutamate injections, but not one-glutamate injection, significantly decreased PPTs in the local pain area, with no significant gender differences. No PPTs changes were observed either in the contralateral trapezius muscle or bilaterally in the referred pain areas in either sex. These results suggest that a less efficient pain habituation and a greater susceptibility to the development of temporal summation of muscle pain in females, but not in males, might be one of the contributing factors to the higher incidence of neck shoulder pain in females. In addition, the reduction of PPTs in the local pain area evoked by intramuscular glutamate injection may represent an early process of peripheral pressure hyperalgesia, which is most likely gender independent. (C) 2004 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.