Leachability of plasticizer and residual monomer from commercial temporary restorative resins
Leachability of plasticizer and residual monomer from commercial temporary restorative resins
复制标题
DOI：
10.1016/j.jdent.2003.12.004
复制
发表时间：
2004-05-01
影响因子：
4.4
通讯作者：
Shintani, H
中科院分区：
文献类型：
--
作者：
Kawahara, T;Nomura, Y;Shintani, H
目标.本研究旨在确定商业暂时修复树脂的组成，并评估增塑剂和残留单体的可溶解性。采用气相色谱-质谱联用仪（GCMS）和高效液相色谱法（HPLC）检测了四种市售暂时性修复树脂（Dura Seat、Fit Seat、Plast Seat Quick和Poly Seat）中的化学物质。采用高效液相色谱法测定了固化树脂在乙醇中浸泡1 h ~ 14 d后，树脂中增塑剂和残留单体的溶出量。用作增塑剂的邻苯二甲酸酯含有40-55重量%的邻苯二甲酸二正丁酯（DBP）或邻苯二甲酰丁基乙醇酸丁酯。树脂单体包括甲基。在一个实施方案中，将甲基丙烯酸2-羟乙酯（MMA）或MMA和甲基丙烯酸2-羟乙酯（HEMA）的混合物加入到混合物中;加入二甲基丙烯酸1，3-丁二醇酯作为交联剂。每种树脂含有40-60重量%的单体。浸提的邻苯二甲酸酯的量随着浸泡时间的增加而增加，达到120-190 μ g/mg，随后没有变化。残余单体逐渐浸出，最多可达3d，随后没有变化。在储存3天后，浸出的残留单体（MMA、HEMA）的量为2090 μ g/mg。超过50%的可沥滤增塑剂和单体分别在24和3 h内从固化树脂中洗脱。与内分泌干扰物的浓度及其潜在的遗传毒性效应相比，沥滤的增塑剂和残留单体的量非常大。因此，评价这些化合物从暂时性修复树脂中的浸出性是非常重要的。(C)2003 Elsevier Ltd.保留所有权利。
Objectives. This study was performed to determine the compositions of commercial temporary restorative resins and to evaluate the leachability of plasticizer and residual monomer from them.Methods. The chemicals in four commercial temporary restorative resins (Dura Seat, Fit Seat, Plast Seat Quick, and Poly Seat) were detected by GCMS and HPLC. The amounts of plasticizers and residual monomers that leached from cured resin samples immersed in ethanol for 1 h to 14 d were determined by HPLC.Results. Phthatate esters used as plasticizers contained 40-55 wt% either di-n-butyl phthalate (DBP) or butyl, phthalyl butyl glycolate. The resin monomer included methyl. methacrylate (MMA) or a mixture of MMA and 2-hydroxyethyl methacrylate (HEMA); 1,3-butanediol dimethacrylate was added as a cross-linking agent. Each resin contained 40-60 wt% monomer. The amounts of phthalate esters Leached increased with immersion time up to 7d, reaching 120-190 mug/mg, and did not change subsequently. The residual monomers leached gradually for up to 3d and did not change subsequently. The amount of leached residual monomer (MMA, HEMA) was 2090 mug/mg after 3 d storage. More than 50% of the leachable plasticizers and monomers were eluted from the cured resins within 24 and 3 h, respectively.Conclusions. The amounts of leached plasticizers and residual monomers were extremely large compared with the concentrations of endocrine disrupters and their potentially genotoxic effects. Therefore, it is very important to evaluate the Leachability of these compounds from temporary restorative resins. (C) 2003 Elsevier Ltd. All rights reserved.