Visible light photocatalytic acyldifluoroalkylation of unactivated alkenes for the direct synthesis of gem- difluorinated ketones
Visible light photocatalytic acyldifluoroalkylation of unactivated alkenes for the direct synthesis of gem- difluorinated ketones
复制标题
未活化烯烃的可见光催化酰基二氟烷基化直接合成偕二氟酮
DOI：
10.1039/c9qo00136k
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发表时间：
2019
影响因子：
5.4
通讯作者：
Zhu Gangguo
中科院分区：
文献类型：
--
作者：
Zhou Yulu;Xiong Zhimin;Qiu Jiayan;Kong Lichun;Zhu Gangguo
以二氟乙酸为二氟烷基化试剂，邻苯二甲酸二丁酯为氧化剂，在可见光下进行了未活化烯烃的酰基二氟烷基化反应。本发明在室温下有效地合成了多种偕二氟代环酮，包括色满-4-酮、茚满酮、3，4-二氢萘-1（2 H）-酮、2，3-二氢喹啉-4（1H）-酮和环戊二烯-2-烯酮，具有优异的官能团相容性。
A visible-light-induced acyldifluoroalkylation of unactivated alkenes with difluoroacetic acids as the difluoroalkylation reagent and PhI(OAc)2 as the oxidant is described. Various gem-difluorinated cyclic ketones, including chroman-4-ones, indanones, 3,4-dihydronaphthalen-1(2H)-ones, 2,3-dihydroquinolin-4(1H)-ones, and cyclopent-2-enones, are efficiently synthesized with excellent functional group compatibility at room temperature.