Development of a multi-use human-scale single-ring OpenPET system
Development of a multi-use human-scale single-ring OpenPET system
复制标题
开发多用途人体规模单环 OpenPET 系统
DOI：
10.1109/trpms.2020.3037055
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发表时间：
2020
影响因子：
4.4
通讯作者：
Taiga Yamaya
中科院分区：
文献类型：
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作者：
Hideaki Tashima;Eiji Yoshida;Yuma Iwao;Hidekatsu Wakizaka;Akram Mohammadi;Munetaka Nitta;Atsushi Kitagawa;Taku Inaniwa;Fumihiko Nishikido;Atsushi B Tsuji;Yuji Nagai;Chie Seki;Takafumi Minamimoto;Yasuhisa Fujibayashi;Taiga Yamaya
我们开发了一个人类规模的单环OpenPET（SROP）系统，它有一个开放的空间，允许我们在测量过程中接近受试者。SROP系统由160个4层相互作用深度探测器组成。通过214 mm的环轴向宽度和660 mm的环内径实现了轴向宽度为430 mm的开放空间。检测器彼此轴向移动，使得检测器环沿着与轴向方向水平倾斜45°的平面对齐。该系统被开发为一种移动的扫描仪，不仅用于临床正电子发射断层扫描（PET）室，还用于带电粒子治疗室以及动物实验室。通过迭代图像重建方法，在整个视场（FOV）中实现了优于3 mm的几乎均匀的空间分辨率。峰值绝对灵敏度为3.1%，有一个区域的灵敏度优于0.8%的长度超过700 mm。在重离子医疗加速器在千叶进行的束内成像实验表明，该系统是可操作的，即使在最高的束流强度可用于重离子治疗。此外，我们通过将猴子沿具有最长FOV的方向定位沿着与轴向倾斜45°，利用机架内的长区域进行全身猴子动态成像。我们的结论是，开发的系统有能力实现多功能PET应用，利用其广阔的开放空间和流动性，除了高空间分辨率与足够好的灵敏度。-9mm]为了清楚起见，请考虑重新措辞“我们得出了已开发系统的结论”。
We developed a human-scale single-ring OpenPET (SROP) system, which had an open space allowing us access to the subject during measurement. The SROP system consisted of 160 4-layer depth-of-interaction detectors. The open space with the axial width of 430 mm was achieved with the ring axial width of 214 mm and the ring inner diameter of 660 mm. The detectors were axially shifted to each other so that the detector ring was aligned along a plane horizontally tilted by 45° against the axial direction. The system was developed as a mobile scanner to be used not only in clinical positron emission tomography (PET) rooms but also in charged-particle therapy treatment rooms as well as animal experiment rooms. Almost uniform spatial resolution better than 3 mm throughout the entire field of view (FOV) was realized with an iterative image reconstruction method. Peak absolute sensitivity was 3.1%, and there was a region with sensitivity better than 0.8% for a length of more than 700 mm. An in-beam imaging experiment conducted at the heavy ion medical accelerator in Chiba showed that the system was operable even at the highest beam intensity available for heavy-ion therapy. In addition, we conducted entire-body monkey dynamic imaging utilizing the long region inside the gantry by positioning a monkey along the direction having the longest FOV tilted by 45° against the axial direction. We concluded the developed system has a capability to realize versatile PET applications by utilizing its wide-open space and mobility in addition to high spatial resolution with sufficiently good sensitivity. -9mm]Please consider rephrasing the sentence “We concluded the developed system” for clarity.