Effect of β-lactotensin on acute stress and fear memory
Effect of β-lactotensin on acute stress and fear memory
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DOI：
10.1016/j.peptides.2006.08.009
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发表时间：
2006-12-01
期刊：
影响因子：
3
通讯作者：
Wada, Keiji
中科院分区：
文献类型：
--
作者：
Yamauchi, Rena;Wada, Etsuko;Wada, Keiji
β-乳压素(beta-Lactotensin，β-LT)是从牛乳中提取的一种生物活性多肽，是神经降压素受体的天然配体。我们研究了β-LT对小鼠束缚应激和恐惧记忆的影响。在孔板测试中，受到急性束缚应激的小鼠与非应激对照组相比，头部下沉的次数减少，头部下沉潜伏期延长，反映出应激诱导行为的增加。然而，事先给予β-LT可改善应激引起的行为。神经降压素受体亚型2(NTR2)拮抗剂左卡巴斯汀可阻断β-LT的抗应激作用。在恐惧条件反射测试中，与对照组相比，服用β-LT的小鼠通过线索恐惧条件反射的冻结反应持续时间显著缩短。这些结果表明，β-LT具有抗应激作用，并促进恐惧记忆的消退，这可能是由NTR2介导的。(C)2006 Elsevier Inc.保留所有权利。
beta-Lactotensin (beta-LT) is a bioactive peptide derived from bovine milk beta-lactoglobulin and is a natural ligand for neurotensin receptors. We examined the effect of beta-LT on restraint stress and fear memory in mice. Mice subjected to acute restraint stress exhibited a decreased number of head-dips and increased head-dip latency compared to non-stressed controls in the hole-board test, reflecting increased stress-induced behaviors. However, prior administration of beta-LT improved the behaviors caused by stress. The anti-stress effect of beta-LT was blocked by levocabastine, a neurotensin receptor subtype 2 (NTR2) antagonist. In the fear-conditioning test, the duration of freezing responses by cued fear conditioning was significantly reduced in mice administered beta-LT compared with control mice. These results suggest that beta-LT has an anti-stress effect and promotes the extinction of fear memory, which may be mediated by NTR2. (c) 2006 Elsevier Inc. All rights reserved.