Recombinant HDL-like nanoparticles: A specific contrast agent for MRI of atherosclerotic plaques
Recombinant HDL-like nanoparticles: A specific contrast agent for MRI of atherosclerotic plaques
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DOI：
10.1021/ja044911a
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发表时间：
2004-12-22
影响因子：
15
通讯作者：
Fayad, ZA
中科院分区：
文献类型：
--
作者：
Frias, JC;Williams, KJ;Fayad, ZA
制备了一种基于重组高密度脂蛋白样纳米颗粒的新型MRI造影剂。由于它对斑块具有选择性，并且是一种内源性分子，因此在相对较短的时间内（注射后24小时）作为动脉粥样硬化斑块的造影剂显示出巨大的潜力。它还可以区分不同类型的斑块，因为所获得的增强不同，取决于斑块的组成。
A new contrast agent for MRI based on recombinant HDL-like nanoparticles has been prepared. It shows a great potential as a contrast agent for atherosclerotic plaques in a relative short time (24 h post-injection) as it is selective for the plaques and is an endogenous molecule. It also can distinguish between different types of plaques as the enhancement obtained is different, depending on plaque composition.