Increased serum levels of advanced glycation endproducts predict total, cardiovascular and coronary mortality in women with type 2 diabetes:: a population-based 18 year follow-up study
Increased serum levels of advanced glycation endproducts predict total, cardiovascular and coronary mortality in women with type 2 diabetes:: a population-based 18 year follow-up study
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DOI：
10.1007/s00125-007-0687-z
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发表时间：
2007-07-01
期刊：
影响因子：
8.2
通讯作者：
Laakso, M.
中科院分区：
文献类型：
--
作者：
Kilhovd, B. K.;Juutilainen, A.;Laakso, M.
AGEs是蛋白质和脂质糖基化或糖氧化形成的修饰产物，与糖尿病患者的过早动脉粥样硬化有关。我们调查是否增加血清AGEs预测总的，心血管（CVD）或CHD的死亡率在一个人口为基础的study.Subjects和方法血清AGEs水平测定874芬兰糖尿病研究参与者（488名男性，386名女性），年龄45 - 64岁的随机样本免疫分析。这些参与者进行了为期18年的总，CVD和CHD mortarity.Results多元考克斯回归模型显示，血清AGEs水平显着相关的总（p= 0.002）和CVD死亡率（p= 0.021）的女性，但不是在男性。血清AGEs水平在最高的性别特异性四分位数预测全因（风险比[HR] 1.51; 95%置信区间[CI]，1.14 - 1.99; p= 0.004），CVD（HR 1.56; 95% CI 1.12 - 2.19; p= 0.009）和CHD（HR 1.68; 95% CI 1.11 - 2.52; p= 0.013）女性死亡率，即使调整混杂因素后，结论/解释血清AGEs水平升高可预测2型糖尿病女性总死亡率和心血管死亡率。
Aims/hypothesis AGEs, modification products formed by glycation or glycoxidation of proteins and lipids, have been linked to premature atherosclerosis in patients with diabetes. We investigated whether increased serum levels of AGEs predict total, cardiovascular (CVD) or CHD mortality in a population-based study.Subjects and methods Serum levels of AGEs were determined by immunoassay in a random sample of 874 Finnish diabetic study participants ( 488 men, 386 women), aged 45 - 64 years. These participants were followed for 18 years for total, CVD and CHD mortality.Results Multivariate Cox regression models revealed that serum levels of AGEs were significantly associated with total (p= 0.002) and CVD mortality ( p= 0.021) in women, but not in men. Serum levels of AGEs in the highest sex-specific quartile predicted all-cause ( hazards ratio [HR] 1.51; 95% confidence intervals [CI], 1.14 - 1.99; p= 0.004), CVD ( HR 1.56; 95% CI 1.12 - 2.19; p= 0.009), and CHD ( HR 1.68; 95% CI 1.11 - 2.52; p= 0.013) mortality in women, even after adjustment for confounding factors, including high-sensitivity C-reactive protein.Conclusions/interpretation Increased serum levels of AGEs predict total and CVD mortality in women with type 2 diabetes.