IL-1 induces IGF-dependent epithelial proliferation in prostate development and reactive hyperplasia.
IL-1 induces IGF-dependent epithelial proliferation in prostate development and reactive hyperplasia.
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DOI：
10.1126/scisignal.2000338
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发表时间：
2009-09-01
影响因子：
7.3
通讯作者：
Bushman W
中科院分区：
文献类型：
--
作者：
Jerde TJ;Bushman W
Chronic inflammation and reactivation of developmental signaling pathways are both hallmarks of adenocarcinomas. However, developmental biology and inflammation are generally thought of as distinct and are believed to represent separate paths to carcinogenesis. Here, we show that the inflammatory cytokine IL-1α plays a critical role in prostate development by activating insulin-like growth factor signaling; this process is reiterated during inflammatory reactive hyperplasia to elicit epithelial proliferation. The appearance of developmental signals during hyperplasia supports the hypothesis that reactivation of developmental signaling plays a role in the hyperplasic reaction to inflammation and suggests that there may be a conserved link between inflammatory signaling and canonical developmental pathways.
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影响因子：
6.2
作者：
Sims, NA;Jenkins, BJ;Martin, TJ
通讯作者：
Martin, TJ
DOI：
10.1073/pnas.222537099
发表时间：
2002-10-29
影响因子：
11.1
作者：
Ide, H;Seligson, DB;Witte, ON
通讯作者：
Witte, ON
影响因子：
3.8
作者：
Abcouwer, SF;Norman, J;Souba, WW
通讯作者：
Souba, WW
影响因子：
6.2
作者：
Ricote, M;García-Tuñón, I;Royuela, M
通讯作者：
Royuela, M
影响因子：
2.7
作者：
Cook, Crist;Vezina, Chad M.;Bushman, Wade
通讯作者：
Bushman, Wade