Introductory article for Immunological Reviews, Vol 310.
Introductory article for Immunological Reviews, Vol 310.
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《免疫学评论》的介绍性文章，第 310 卷。
DOI：
10.1111/imr.13128
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发表时间：
2022
影响因子：
8.7
通讯作者：
Feinberg,MarkB
中科院分区：
文献类型：
--
作者：
Burton,DennisR;Feinberg,MarkB
2019年底在中国武汉首次发现的冠状病毒SARS-CoV-2的出现对人类产生了毁灭性影响。据估计，迄今为止约有1500万人死于COVID-19疾病，发病率高出许多倍。这一流行病造成的经济损失是巨大的。据估计，到2025年，全球GDP损失的成本将达到22万亿美元。然而，毫无疑问，如果不是疫苗和治疗方法的快速发展，SARS-CoV-2的死亡人数和损害可能会更严重。在过去的二十年里，这些快速的发展无疑是由对病毒以及病毒与免疫系统之间相互作用的研究所推动的。特别值得注意的是，艾滋病毒研究人员为我们理解和应对SARS-CoV-2做出了一些关键贡献。令人关切的变异的出现表明，在获得对这一流行病的可接受控制方面仍有一些路要走，因此有必要继续进行研究。此外，新型冠状病毒大流行为全球人口面对迅速蔓延的传染病的脆弱性敲响了警钟。我们需要优先考虑更好地了解具有大流行潜力的病原体，并开发工具，以比我们今天更高的水平应对它们。
The emergence of a coronavirus, SARS-CoV-2, first identified in Wuhan, China, at the end of 2019, has had a devastating effect on humanity. It is estimated that approximately 15 million have died of COVID-19 disease to date, and morbidity is many fold higher. The economic damage caused by the pandemic is huge. It has been estimated that the costs in terms of lost global GDP will amount to $22 trillion dollars by 2025.However, there is little doubt that the death toll and the damage could have been much worse were it not for the rapid development of vaccines and therapies to respond to SARS-CoV-2. These rapid developments were undoubtably facilitated by research that has gone on understanding viruses and the interplay between viruses and the immune system in the last two decades. In particular, it is noteworthy that HIV researchers have made some of the key contributions to our understanding and response to SARS-CoV-2. The emergence of variants of concern shows that there is still some way to go in gaining acceptable control of the pandemic, so that continued research will be necessary. Furthermore, the COVID pandemic is a wakeup call with regard to the vulnerability of our global population to rapidly spreading infectious disease. We need to prioritize greater understanding of pathogens with pandemic potential and develop the tools to respond to them to an even higher level than we have today.