Review of the Emerging Treatment of Clostridium difficile Infection with Fecal Microbiota Transplantation and Insights into Future Challenges
Review of the Emerging Treatment of Clostridium difficile Infection with Fecal Microbiota Transplantation and Insights into Future Challenges
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DOI：
10.1016/j.cll.2014.08.007
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发表时间：
2014-12-01
影响因子：
1.7
通讯作者：
Hunt, Richard H.
中科院分区：
文献类型：
--
作者：
Kassam, Zain;Lee, Christine H.;Hunt, Richard H.
艰难梭菌感染(CDI)是美国最常见的卫生保健相关感染之一。目前，还没有标准化的方法来制备或传递粪便微生物区系移植(FMT)。制备FMT的方法有多种，通常通过鼻胃管、结肠镜或灌肠给药。几项临床试验正在进行中，以评估FMT治疗CDI的真正有效性和安全性。这些试验包括CDI研究，通过结肠镜和冷冻胶囊评估FMT，通过灌肠法评估新鲜FMT与冻融FMT，比较FMT与万古霉素锥度，以及在儿科人群中评估FMT。
Clostridium difficile infection (CDI) is one of the most common health care-associated infections in the United States. Currently, there are no standardized methods to prepare or deliver the fecal microbiota transplantation (FMT). Various methods are used to prepare the FMT, which is usually administered via nasogastric tube, colonoscopy, or by enema. Several clinical trials are underway to assess the true efficacy and safety of FMT for CDI. These trials include CDI studies assessing FMT via colonoscopy and frozen encapsulation, fresh versus frozen-and-thawed FMT by enema, FMT compared with a vancomycin taper, and FMT in the pediatric population.