Language and calculation within the parietal lobe:: a combined cognitive, anatomical and fMRI study
Language and calculation within the parietal lobe:: a combined cognitive, anatomical and fMRI study
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DOI：
10.1016/s0028-3932(00)00038-5
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发表时间：
2000-01-01
期刊：
影响因子：
2.6
通讯作者：
Naccache, L
中科院分区：
文献类型：
--
作者：
Cohen, L;Dehaene, S;Naccache, L
我们报告一位病人(ATH)，在她的左侧乙状旁区受损后，出现了失语症、深度阅读障碍和失算。她在所有涉及口头形式的数字的任务中都表现出严重的障碍，如朗读、听写或口头回答数字知识问题。相比之下，她处理数字的非语言表征，即阿拉伯数字和数量的能力得到了相对较好的保留，例如在数字比较或数字二等分任务中得到了证明。这种语言和非语言数字能力的分离损害导致了四种算术运算的不同损害。ATS在减法和加法方面的表现比乘法和除法要好得多，减法和加法可以在数量操作的基础上解决，乘法和除法问题通常通过检索存储的单词序列来解决。大脑损伤影响了经典语言区域，但没有影响在计算任务中活跃的左侧顶下小叶的一部分，正如功能磁共振所显示的那样。最后，减法和乘法的相对保存可能与这样一个事实有关：减法激活了完整的右侧顶叶，而乘法激活了主要是左侧区域。(C)2000爱思唯尔科学有限公司。保留所有权利。
We report the case of a patient (ATH) who suffered from aphasia, deep dyslexia, and acalculia, following a lesion in her left perisylvian area. She showed a severe impairment in all tasks involving numbers in a verbal format, such as reading aloud, writing to dictation, or responding verbally to questions of numerical knowledge. In contrast, her ability to manipulate nonverbal representations of numbers, i.e., Arabic numerals and quantities, was comparatively well preserved, as evidenced for instance in number comparison or number bisection tasks. This dissociated impairment of verbal and non-verbal numerical abilities entailed a differential impairment of the four arithmetic operations. ATH performed much better with subtraction and addition, that can be solved on the basis of quantity manipulation, than with multiplication and division problems, that are commonly solved by retrieving stored verbal sequences. The brain lesion affected the classical language areas, but spared a subset of the left inferior parietal lobule that was active during calculation tasks, as demonstrated with functional MRI. Finally, the relative preservation of subtraction versus multiplication may be related to the fact that subtraction activated the intact right parietal lobe, while multiplication activated predominantly left-sided areas. (C) 2000 Elsevier Science Ltd. All rights reserved.