INHIBITION OF T-3-RECEPTOR BINDING BY NITROFEN
INHIBITION OF T-3-RECEPTOR BINDING BY NITROFEN
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DOI：
10.1016/0304-4165(94)90050-7
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发表时间：
1994-11-11
影响因子：
3
通讯作者：
WIERSINGA, WM
中科院分区：
文献类型：
--
作者：
BRANDSMA, AE;TIBBOEL, D;WIERSINGA, WM
肺部发育受多种激素控制，包括甲状腺激素。在妊娠期间给母鼠服用除草剂 2,4-二氯苯基-对硝基苯醚（硝基芬）会导致胎鼠肺发育不全。硝基芬可能因抗甲状腺活性而致畸。本研究表明 Nitrofen 以非竞争性方式减少 T-3 与甲状腺激素受体 α(1) 和 β(1) 形式的结合。因此，大鼠肺发育不全可能是由于胎儿发育期间暴露于硝基芬导致 T-3 与其受体的结合减少所致。
Lung development is controlled by various hormones, including thyroid hormone. The herbicide 2,4-dichlorophenyl-p-nitrophenyl ether (Nitrofen) induces lung hypoplasia in fetal rats, when administered to the mother during gestation. Nitrofen might be teratogenic by an anti-thyroid activity. The present study shows that Nitrofen decreases the binding of T-3 to the alpha(1) and beta(1) form of the thyroid hormone receptor in a non-competitive way. Consequently, rat lung hypoplasia might result from the decreased binding of T-3 to its receptor, via exposure to Nitrofen during fetal development.