Early warning and clinical outcome prediction of acute-onchronic hepatitis B liver failure
Early warning and clinical outcome prediction of acute-onchronic hepatitis B liver failure
复制标题
慢性乙型肝炎肝衰竭的早期预警和临床结果预测。
DOI：
10.3748/wjg.v21.i42.11964
复制
发表时间：
2015-11-14
影响因子：
4.3
通讯作者：
Tang, Hong
中科院分区：
文献类型：
--
作者：
Chen, En-Qiang;Zeng, Fan;Tang, Hong
乙型肝炎病毒（HBV）相关的急性慢性肝衰竭（ACLF）是一种越来越被认为是致命的肝脏疾病，包括慢性乙型肝炎（CHB）患者肝功能的严重急性恶化。尽管引入了人工肝支持系统和抗病毒治疗，但HBV-ACLF的短期预后仍然非常差，除非进行紧急肝移植。在这种情况下，早期停止或减缓CHB向ACLF的进展是降低HBV-ACLF发病率和死亡率的最有效方法。众所周知，HBV-ACLF的发生和发展与许多因素有关，如果给予及时、适当的干预，HBV-ACLF患者的预后可以得到显著改善。在这篇综述中，我们重点介绍了HBV-ACLF患者早期预警和临床预后预测的最新进展，并对该领域的未来研究进行了展望。
Hepatitis B virus (HBV) associated acute-on-chronic liver failure (ACLF) is an increasingly recognized fatal liver disease encompassing a severe acute exacerbation of liver function in patients with chronic hepatitis B (CHB). Despite the introduction of an artificial liver support system and antiviral therapy, the short-term prognosis of HBV-ACLF is still extremely poor unless emergency liver transplantation is performed. In such a situation, stopping or slowing the progression of CHB to ACLF at an early stage is the most effective way of reducing the morbidity and mortality of HBV-ACLF. It is well-known that the occurrence and progression of HBV-ACLF is associated with many factors, and the outcomes of HBV-ACLF patients can be significantly improved if timely and appropriate interventions are provided. In this review, we highlight recent developments in early warning and clinical outcome prediction in patients with HBV-ACLF and provide an outlook for future research in this field.