SEASONAL-VARIATION IN THE HUMAN CIRCADIAN-RHYTHM - DISSOCIATION BETWEEN SLEEP AND TEMPERATURE RHYTHM
SEASONAL-VARIATION IN THE HUMAN CIRCADIAN-RHYTHM - DISSOCIATION BETWEEN SLEEP AND TEMPERATURE RHYTHM
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DOI：
10.1152/ajpregu.1992.262.5.r885
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发表时间：
1992-05-01
影响因子：
--
通讯作者：
FUKUDA, N
中科院分区：
文献类型：
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作者：
HONMA, KI;HONMA, S;FUKUDA, N
连续五个季节测量了 10 名健康男性受试者的睡眠-觉醒、直肠温度和血浆褪黑激素的昼夜节律。 为了尽量减少季节性变化的环境因素的直接影响，受试者每个季节在生活设施中呆4天，其中环境温度、湿度和社交接触受到控制，而客厅的光强度很大程度上受到自然光的影响。 睡眠时间、平均体温、昼夜节律和褪黑激素节律的相位以及睡眠和直肠温度节律之间的相位关系都存在季节性变化。 受试者在夏季入睡最早，春季和秋季居中，冬季最晚。 在起床时间中观察到类似但更明显的季节性，夏季比冬季早。 通过拟合余弦曲线计算得出的直肠温度和血浆褪黑激素节律的顶相在夏季比冬季位于一天中更早的时间。 直肠温度节律与睡眠的相位角差异随季节变化，并且夏季比冬季更正。 这些发现表明，人类昼夜节律的外部（当地时间）和内部（昼夜节律之间）相位关系都取决于季节。
The circadian rhythms of sleep-wakefulness, rectal temperature, and plasma melatonin were measured in 10 healthy male subjects for five consecutive seasons. To minimize direct effects of seasonally changing environmental factors, the subjects stayed in a living facility for 4 days in each season, where ambient-temperature, humidity, and social contacts were controlled, while the light intensity of the living room was substantially influenced by natural daylight. Seasonal variations were found in the timing of sleep, the mean body temperature, the phases of circadian temperature and melatonin rhythms, and the phase relation between sleep and the rectal temperature rhythm. The subjects went to bed earliest in summer, intermediate in spring and autumn, and latest in winter. A similar but more pronounced seasonality was observed in the wake-up time, which was earlier in summer than in winter. The acrophases of the rectal temperature and plasma melatonin rhythms, which were calculated by fitting a cosine curve, were located in an earlier time of day in summer than in winter. The phase-angle difference of the rectal temperature rhythm to sleep varied seasonally and was more positive in summer than in winter. These findings indicate that not only the external (to the local time) but also the internal (between circadian rhythms) phase relations of the human circadian rhythms depend on season.