Serum Trace Elements Levels in Preeclampsia and Eclampsia: Correlation with the Pregnancy Disorder
Serum Trace Elements Levels in Preeclampsia and Eclampsia: Correlation with the Pregnancy Disorder
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DOI：
10.1007/s12011-013-9637-4
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发表时间：
2013-06-01
影响因子：
3.9
通讯作者：
Islam, Sheikh Nazrul
中科院分区：
文献类型：
--
作者：
Ahsan, Touhida;Banu, Salina;Islam, Sheikh Nazrul
先兆子痫和子痫是妊娠的致命医学并发症，占发展中国家孕产妇死亡增加的20- 80%。其病因仍在调查中。血清微量元素与子痫前期的发病有关。本研究旨在探讨血清微量元素与子痫前期及子痫的相关性。这是一个比较横断面研究进行了方便招募44先兆子痫，子痫33例和27例正常血压的孕妇。采用原子吸收分光光度法测定血清Ca、Mg、Cu、Zn、Fe含量。资料以学生t检定、单因子变异数分析、多项逻辑及二元回归分析进行分析。p < 0.05被认为是显著性水平。子痫前期组血清Ca、Mg明显低于子痫组，而Cu、Zn明显高于子痫组。子痫前期组、子痫组和妊娠对照组的Ca、Mg、Cu含量均显著高于正常对照组。子痫前期患者血清钙、镁水平呈正相关，铜水平呈负相关。子痫组Cu/Fe比值增高。在子痫中，Mg与Zn显著相关，在子痫前期和子痫中，Mg与Fe显著相关。子痫前期和子痫患者血清微量元素水平明显改变，可能与妊娠期疾病的发生有关。
Preeclampsia and eclampsia are fatal medical complications of pregnancy accounting for 20-80 % of increased maternal death in developing countries. Their aetiologies are still under investigation. Serum trace elements have been suggested to be involved in the pathogenesis of preeclampsia. Aim of this study was to address the correlation of serum trace elements with preeclampsia and eclampsia. It was a comparative cross-sectional study conducted on conveniently recruited 44 preeclampsia, 33 eclampsia and 27 normotensive pregnant patients. Atomic absorption spectrometry was employed to analyse serum concentrations of Ca, Mg, Cu, Zn and Fe. Data were analysed by Student's t test, one-way analysis of variance and multinomial logistic and binary regression analyses. p < 0.05 was considered as a level of significance. In preeclampsia, the serum Ca and Mg were significantly lower than those in eclampsia, while Cu and Zn values were higher. Significant changes of Ca, Mg and Cu were noted among preeclampsia, eclampsia and pregnant control. Serum Ca and Mg indicated a positive association, and Cu gave a negative association in preeclampsia. Cu/Fe ratio was high in eclampsia. Significant correlations of Mg with Zn in eclampsia and Mg with Fe in preeclampsia and eclampsia were predicted. Significant changes in serum trace element levels were present in preeclampsia and eclampsia that may have a link with the pathogenesis of pregnancy disorder.