Biphasic calcium phosphate nanocomposite porous scaffolds for load-bearing bone tissue engineering
Biphasic calcium phosphate nanocomposite porous scaffolds for load-bearing bone tissue engineering
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DOI：
10.1016/j.biomaterials.2003.12.023
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发表时间：
2004-09-01
期刊：
影响因子：
14
通讯作者：
Zhang, M
中科院分区：
文献类型：
--
作者：
Ramay, HRR;Zhang, M
研制了一种新型的生物可降解纳米复合多孔支架材料，该材料由β-磷酸三钙（β-TCP）和羟基磷灰石（HA）纳米纤维组成，可用于承重骨组织工程。采用仿生沉淀法制备了HA纳米纤维。采用凝胶注模成型和聚合物海绵相结合的方法制备复合支架。研究了HA纳米纤维在增强支架力学性能中的作用。进行压缩测试以测量多孔支架的压缩强度、模量和韧性。通过X射线衍射和透射电子显微镜对HA纳米纤维的形貌和结构进行了表征。扫描电子显微镜用于检查多孔支架和断裂表面的形态，以揭示占主导地位的增韧机制。结果表明，HA纳米纤维的加入显著提高了支架的力学性能。多孔复合支架达到9.8 +/- 0.3 MPa的压缩强度，与松质骨的高端值（2- 10 MPa）相当。随着HA纳米纤维的浓度从0增加到5wt%，支架的韧性从1.00 +/-0.04增加到1.72 +/-0.02kN/m。(C)2003爱思唯尔有限公司。保留所有权利。
A novel biodegradable nanocomposite porous scaffold comprising a beta-tricalcium phosphate (beta-TCP) matrix and hydroxyl apatite (HA) nanofibers was developed and Studied for load-bearing bone tissue engineering. HA nanofibers were prepared with a biomimetic precipitation method. The composite scaffolds were fabricated by a method combining the gel casting and polymer sponge techniques. The role of HA nanofibers in enhancing the mechanical properties of the scaffold was investigated. Compression tests were performed to measure the compressive strength, Modulus and toughness of the porous scaffolds. The identification and morphology of HA nanofibers were determined by X-ray diffraction and transmission electron microscopy, respectively. Scanning electron microscopy was used to examine the morphology of porous scaffolds and fracture surfaces to reveal the dominant toughening mechanisms. The results showed that the mechanical property of the scaffold was significantly enhanced by the inclusion of HA nanofibers. The porous composite scaffold attained a compressive strength of 9.8 +/- 0.3 M Pa, comparable to the high-end value (2-10MPa) of cancellous bone. The toughness of the scaffold increased from 1.00 +/- 0.04 to 1.72 +/- 0.02 kN/m, as the concentration of HA nanofibers increased from 0 to 5 wt %. (C) 2003 Elsevier Ltd. All rights reserved.