The role of oxidative stress in the pathogenesis of socially significant human diseases and ways of its drug correction
The role of oxidative stress in the pathogenesis of socially significant human diseases and ways of its drug correction
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氧化应激在人类重大社会疾病发病机制中的作用及其药物纠正方法
DOI：
10.14300/mnnc.2021.16109
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
T. V. Alexandrova
中科院分区：
文献类型：
--
作者：
Yu. V. Olefir;B. Romanov;V. Kukes;D. Sychev;A. Prokofiev;O. K. Parfenova;N. G. Sidorov;T. V. Alexandrova
这篇综述文章描述了氧化应激在具有社会意义的病理发展中的作用及其中和方法。结果表明，在不同的病理情况下，氧化应激的机制是相同的，但其发展的后果可能不同。研究发现，氧化应激是新型冠状病毒严重感染的主要致病因素之一，伴随着血液和组织中酸性产物的积聚和促炎细胞因子水平的升高。介绍了抗氧化剂的各种分类，以及国产低毒抗氧化剂：含有琥珀酸、肌苷、烟酰胺和核黄素的医药产品，苹果酸甲基羟基吡啶和琥珀酸甲基羟基吡啶的药理作用。
The review article describes the role of oxidative stress in the development of socially significant pathologies and approaches to its neutralization. It is shown that the mechanism of oxidative stress is the same in different pathologies, but the consequences of its development may differ. It was found that oxidative stress is one of the main factors in the pathogenesis of severe forms of new coronavirus infection, accompanied by the accumulation of acidic products in the blood and tissues and an increase in the level of Pro-inflammatory cytokines. Various classifications of antioxidant drugs are presented, as well as the pharmacotherapeutic capabilities of domestic low-toxic antioxidants: medicinal product containing succinic acid, inosine, nicotinamide and riboflavin, ethyl methyl hydroxypyridine malate and ethyl methyl hydroxypyridine succinate.