Role of the Host Defense System and Intestinal Microbial Flora in the Pathogenesis of Necrotizing Enterocolitis
Role of the Host Defense System and Intestinal Microbial Flora in the Pathogenesis of Necrotizing Enterocolitis
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DOI：
10.1089/sur.2009.054
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发表时间：
2009-10-01
影响因子：
2
通讯作者：
Ford, Henri R.
中科院分区：
文献类型：
--
作者：
Emami, Claudia N.;Petrosyan, Mikael;Ford, Henri R.
背景：坏死性小肠结肠炎（NEC）是一种主要影响早产儿肠道的毁灭性疾病。尽管在新生儿医学方面取得了最新进展，但NEC仍然是新生儿发病率和死亡率的主要原因。新生儿粘膜防御和细菌病原体的粘附可能在NEC的发病机制中起重要作用。方法：回顾和综合相关文献。结果：与NEC发病机制有关的假定因素包括细菌肠道定植的异常模式、宿主免疫系统和粘膜防御机制的不成熟、肠缺血、配方饲料喂养、结论：宿主防御机制和肠道微生态在NEC的发病机制中起重要作用。共生细菌和益生菌治疗可能在维持肠道上皮屏障方面具有治疗效用。
Background: Necrotizing enterocolitis (NEC) is a devastating disease that affects primarily the intestine of premature infants. Despite recent advances in neonatology, NEC remains a major cause of morbidity and mortality in neonates. Neonatal mucosal defenses and adherence of bacterial pathogens may play an important role in the pathogenesis of NEC.Methods: Review and synthesis of pertinent literature.Results: Putative factors that have been implicated in the pathogenesis of NEC include abnormal patterns of gut colonization by bacteria, immaturity of the host immune system and mucosal defense mechanisms, intestinal ischemia, formula feeding, and loss of intestinal epithelial barrier integrity.Conclusion: Host defenses and intestinal microbial ecology are believed to play important roles in the pathogenesis of NEC. Commensal bacteria and probiotic therapy may be of therapeutic utility in the maintenance of the gut epithelial barrier.