Influence of oncogenicity of Marek' disease virus on evaluation of genetic resistance.
Influence of oncogenicity of Marek' disease virus on evaluation of genetic resistance.
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DOI：
10.3382/ps.0602559
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发表时间：
1981-12
期刊：
影响因子：
4.4
通讯作者：
K. Schat;B. Calnek;J. Fabricant;H. Abplanalp
中科院分区：
文献类型：
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作者：
K. Schat;B. Calnek;J. Fabricant;H. Abplanalp
对马立克氏病（MD）的耐药性部分是由基因决定的，并与主要的组织相容性复合体有关。用JM-10攻毒法测定了9个已鉴定的鸡系、自交系UCD-003和4个基因系的遗传抗性。其中5个品系具有高度抗性。其中包括n系及其两个衍生系（N-2和N-5）、PDRC菌株和一个同源UCD系。PDRC基因型未知，但3个相关系携带B21等位基因，UCD系携带BQ等位基因，似乎与B21相似。UCD-003和其他3个同源品系对JM-10具有中等抗性，而s品系、P-2和P-5品系对JM-10具有高度敏感性。不同系间的MD总发病率从0到100%不等。像GA-5这样的高致癌性病毒分离株，特别是最近分离的RB-1B，在所有品系中引起了高发病率的MD，因此，不允许遗传抗性水平的分化，而致癌性较低的JM-10是可能的。
Resistance to Marek's disease ( MD) is, in part, genetically determined and linked to the major histocompatability complex. The genetic resistance of 9 previously characterized lines of chickens and also of the inbred UCD-003 and 4 congenic lines was evaluated by challenge with JM-10. Five lines were highly resistant. These included the N-line and two derivatives from N-line (N-2 and N-5), PDRC strain, and one of the congenic UCD lines. The PDRC genotype is unknown, but the 3 related lines carry the B21 allele and the UCD line carries the BQ allele, which appears to be similar to B21. The UCD-003 and the other 3 congenic lines were moderately resistant while S-strain, P-2 and P-5 lines were highly susceptible to JM-10. The total MD incidence varied from 0 to 100% among the lines. Challenge with highly oncogenic virus isolates like GA-5, and especially the recently isolated RB-1B, caused high incidences of MD in all lines and, thus, did not permit differentiation of genetic resistance levels as was possible with the less oncogenic JM-10.