Clinical significance of autologous blood transfusions in bone marrow harvest from unrelated donors
Clinical significance of autologous blood transfusions in bone marrow harvest from unrelated donors
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DOI：
10.1007/s12185-020-02851-8
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发表时间：
2020-06-01
影响因子：
2.1
通讯作者：
Muroi, Kazuo
中科院分区：
文献类型：
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作者：
Fujiwara, Shin-ichiro;Ikeda, Kazuhiko;Muroi, Kazuo
在日本骨髓捐献者计划(JMDP)中，自体血液是从大多数不相关的骨髓捐赠者身上采集的。我们通过JMDP对2010至2015年间接受骨髓采集的5772名捐赠者进行了回顾性评估。96.8%的献血者采集了自体血，损失率为0.6%。不需要异体输血。平均血红蛋白(Hb)水平为12.1g/dL(平均891毫升)，加上自体输血(平均596毫升)。采用倾向性-分数匹配法进行背景调整。在骨髓采集量为100-400毫升的供者中，自体输血对采集骨髓后的Hb水平或并发症没有影响。在骨髓采集量为400毫升的献血者中，自体输血较多，随后出血量为300毫升。本研究的结果表明，自体输血给骨髓捐献者在Hb变化和收获后结果方面是过度的。
In the Japan Marrow Donor Program (JMDP), autologous blood is collected from most unrelated bone marrow (BM) donors. We retrospectively evaluated 5772 donors who underwent BM harvest between 2010 and 2015 through the JMDP. Autologous blood was collected in 96.8% of the donors; the wastage rate was 0.6%. Allogeneic blood transfusion was not required. The mean hemoglobin (Hb) levels were 12.1 g/dL after the BM harvest (mean 891 mL) together with autologous blood transfusion (mean 596 mL). Propensity-score matching was used to adjust the backgrounds. Among donors with harvested BM of 100-400 mL, autologous blood transfusion had no impact on Hb levels or complications after BM harvest. Among donors with harvested BM of > 400 mL, more autologous blood transfusion followed by a bleeding volume of 300 mL. The findings of the present study suggest that autologous blood transfusion to BM donors is excessive in terms of Hb changes and post-harvest outcomes.