An event-related fMRI study on risk taking by healthy individuals of high or low impulsiveness
An event-related fMRI study on risk taking by healthy individuals of high or low impulsiveness
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DOI：
10.1016/j.neulet.2008.04.061
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发表时间：
2008-06-20
影响因子：
2.5
通讯作者：
Gao, Jia-Hong
中科院分区：
文献类型：
--
作者：
Lee, Tatia M. C.;Chan, Chetwyn C. H.;Gao, Jia-Hong
这项与事件相关的功能性磁共振成像研究根据Barratt冲动量表（BIS）评分，检查了18名高（n = 9）或低（n = 9）冲动的健康个体与风险收益任务相关的不同神经活动。高冲动组和低冲动组的人在执行风险收益任务时的神经活动由3 T MRI扫描仪监测。我们发现，与低冲动组相比，高冲动组的岛叶-眶额-顶叶区域的激活更强。然而，在外侧前额叶和前扣带区的激活水平并没有两组之间的差异。研究结果表明，神经基板的认知和情感信息的理解与冒险决策可能会有所不同，根据健康个体的冲动。(C)2008爱思唯尔爱尔兰有限公司保留所有权利。
This event-related functional Magnetic Resonance Imaging study examined the differential neural activities associated with a Risky-Gains task in 18 healthy individuals of high (n = 9) or low (n = 9) impulsiveness, according to their scores on the Barratt Impulsiveness Scale (BIS). The neural activities of people belonging to the high and low impulsiveness groups were monitored by a 3T MRI scanner while they were performing the Risky-Gains task. We demonstrated that a stronger activation in the insula-orbitofrontal-parietal regions was found in the high impulsiveness group compared to the low impulsiveness group. However, the levels of activation in the lateral prefrontal and anterior cingulate regions did not differ between the two groups. The findings suggest that the neural substrates of comprehension of cognitive and affective information associated with risk-taking decision making may vary according to the impulsiveness among healthy individuals. (C) 2008 Elsevier Ireland Ltd. All rights reserved.