Pemphigus Vegetans Variant of IgA Pemphigus, a Variant of IgA Pemphigus and Other Autoimmune Blistering Disorders
Pemphigus Vegetans Variant of IgA Pemphigus, a Variant of IgA Pemphigus and Other Autoimmune Blistering Disorders
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素食性天疱疮 IgA 天疱疮变种、IgA 天疱疮变种和其他自身免疫性水疱性疾病
DOI：
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发表时间：
2013
影响因子：
1.1
通讯作者：
A. Bruce
中科院分区：
文献类型：
--
作者：
M. Wolz;M. Camilleri;M. McEvoy;A. Bruce
摘要：脓性皮炎-脓性口炎（PPV）是一种与炎症性肠病相关的炎症性粘膜皮肤病。临床上，PPV表现为粘膜表面的脓疱和间擦表面的渗出性斑块。它通常是由组织学结果支持的临床诊断。镜下发现包括表皮增生、局灶性棘层松解和致密的混合炎症浸润，并伴有上皮内和上皮下嗜酸性微脓肿。在最近的文献中，免疫荧光被认为在 PPV 中呈阴性，或者如果呈阳性，则为异常发现。在此，我们报告了 2 例与炎症性肠病相关的 PPV 病例，其显示细胞间 IgA 沉积。尽管这些病例可能代表孤立的副现象，但迄今为止进行免疫荧光研究的 PPV 病例的缺乏可能导致人们忽视了细胞间 IgA 和 PPV 之间有趣的关联。
Abstract:Pyodermatitis-pyostomatitis vegetans (PPV) constitutes an inflammatory mucocutaneous dermatosis that is associated with inflammatory bowel disease. Clinically, PPV appears as pustules on mucosal surfaces and as vegetating exudative plaques on intertriginous surfaces. It is typically a clinical diagnosis supported by histological findings. Microscopic findings include epidermal hyperplasia, focal acantholysis, and a dense mixed inflammatory infiltrate with intraepithelial and subepithelial eosinophilic microabscesses. In the recent literature, immunofluorescence has been thought to be negative in PPV or, if positive, an aberrant finding. Herein, we report 2 cases of PPV associated with inflammatory bowel disease, which display intercellular IgA deposits. Although these cases may represent isolated epiphenomena, it is possible that the paucity of PPV cases with immunofluorescent studies hitherto has led to an oversight of an interesting association between intercellular IgA and PPV.