Neural correlates of sad faces predict clinical remission to cognitive behavioural therapy in depression
Neural correlates of sad faces predict clinical remission to cognitive behavioural therapy in depression
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DOI：
10.1097/wnr.0b013e3283294159
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发表时间：
2009-05-06
期刊：
影响因子：
1.7
通讯作者：
Fu, Cynthia H. Y.
中科院分区：
文献类型：
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作者：
Costafreda, Sergi G.;Khanna, Akash;Fu, Cynthia H. Y.
目前，在临床实践中使用的认知行为疗法（CBT）没有临床反应的神经生物学标志物。我们研究了悲伤面部表情内隐加工的神经活动模式，作为临床反应的预测标记。16名无药物治疗的重度抑郁症急性发作患者在接受CBT治疗前接受了功能性磁共振成像扫描。9例患者显示完全临床缓解。用支持向量机和留一法交叉验证分析预测临床反应的活性模式。在治疗开始前，悲伤面孔在最低和最高强度下的功能神经解剖学识别出对CBT有完全临床反应的患者（敏感性71%，特异性86%，P = 0.029）。NeuroReport 20：637-641（C）2009 Wolters Kluwer Health竖条Lippincott威廉姆斯& Wilkins.
Currently, there are no neurobiological markers of clinical response for cognitive behavioural therapy (CBT) used in clinical practice. We investigated the neural pattern of activity to implicit processing of sad facial expressions as a predictive marker of clinical response. Sixteen medication-free patients in an acute episode of major depression underwent functional magnetic resonance imaging scans before treatment with CBT. Nine patients showed a full clinical response. The pattern of activity, which predicted clinical response, was analysed with support vector machine and leave-one-out cross-validation. The functional neuroanatomy of sad faces at the lowest and highest intensities identified patients, before the initiation of therapy, who had a full clinical response to CBT (sensitivity 71%, specificity 86%, P = 0.029). NeuroReport 20:637-641 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.