Demographic and clinical characteristics associated with comorbid cannabis use disorders (CUDs) in hospitalized patients with bipolar I disorder.
Demographic and clinical characteristics associated with comorbid cannabis use disorders (CUDs) in hospitalized patients with bipolar I disorder.
复制标题
住院 I 型双相情感障碍患者中与合并大麻使用障碍 (CUD) 相关的人口统计学和临床特征。
DOI：
10.1016/j.comppsych.2015.10.003
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发表时间：
2016
影响因子：
7.3
通讯作者：
Miller,IvanW
中科院分区：
文献类型：
--
作者：
Weinstock,LaurenM;Gaudiano,BrandonA;Wenze,SusanJ;Epstein-Lubow,Gary;Miller,IvanW
背景已发表的数据表明，大麻的使用与双相情感障碍（BD）患者的一些负面后果有关，包括新的躁狂发作、精神病和功能障碍。然而，更少的是知道大麻使用障碍（CUDs）在这个人群中，特别是在更急性症状groups.MethodsTo评估相关的CUD合并症在BD，一个回顾性图表审查进行了230例成人双相I型障碍（BDI）谁被录取到一所大学附属的私立精神病医院。使用计算机算法，医院管理员提取相关的人口统计学和临床数据的电子病历analysis.ResultsThirty-six（16%）有共病CUD。CUD合并症与年轻、躁狂/混合型发作极性、精神病特征的存在以及合并尼古丁依赖、酒精使用障碍（AUD）和其他物质使用障碍显著相关，但与焦虑障碍合并症的可能性降低相关。除了躁狂/混合极性和AUD合并症，控制其他SUDs的存在的多变量分析的结果与单变量findings.ConclusionPatients与BD和合并症CUDs似乎是一个复杂的人群，需要加强临床监测。鉴于公众越来越多地接受大麻的使用，以及针对BD中CUD的循证干预措施的有限性，心理教育和其他治疗开发工作似乎是必要的。
BackgroundPublished data suggest that cannabis use is associated with several negative consequences for individuals with bipolar disorder (BD), including new manic episode onset, psychosis, and functional disability. Yet much less is known about cannabis use disorders (CUDs) in this population, especially in more acutely symptomatic groups.MethodsTo evaluate correlates of CUD comorbidity in BD, a retrospective chart review was conducted for 230 adult patients with bipolar I disorder (BDI) who were admitted to a university-affiliated private psychiatric hospital. Using a computer algorithm, a hospital administrator extracted relevant demographic and clinical data from the electronic medical record for analysis.ResultsThirty-six (16%) had a comorbid CUD. CUD comorbidity was significantly associated with younger age, manic/mixed episode polarity, presence of psychotic features, and comorbid nicotine dependence, alcohol use disorder (AUD), and other substance use disorders, but was associated with decreased likelihood of anxiety disorder comorbidity. With the exception of manic/mixed polarity and AUD comorbidity, results from multivariate analyses controlling for the presence of other SUDs were consistent with univariate findings.ConclusionPatients with BD and comorbid CUDs appear to be a complex population with need for enhanced clinical monitoring. Given increasing public acceptance of cannabis use, and the limited availability of evidenced-based interventions targeted toward CUDs in BD, psychoeducation and other treatment development efforts appear to be warranted.